Thr273
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Home > Phosphorylation Site Page: > Thr273  -  CASP8 (human)

Site Information
DAGALTTtFEELHFE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 56640300

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , phospho-antibody ( 1 , 2 , 4 ) , western blotting ( 2 )
Disease tissue studied:
anal carcinoma ( 2 )
Relevant cell line - cell type - tissue:
anus ( 2 )

Upstream Regulation
Putative in vivo kinases:
PLK3 (human) ( 3 )
Kinases, in vitro:
PLK3 (human) ( 3 )
Treatments:
Fas ( 3 ) , TRAIL ( 3 )

Downstream Regulation
Effects of modification on CASP8:
enzymatic activity, induced ( 3 )

Disease / Diagnostics Relevance
Relevant diseases:
anal carcinoma ( 3 , 4 ) , cervical squamous cell carcinoma ( 1 )

References 

1

Fleischmann M, et al. (2019) Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and Brachytherapy. Front Oncol 9, 742
31475104   Curated Info

2

Balermpas P, et al. (2017) Human papilloma virus load and PD-1/PD-L1, CD8(+) and FOXP3 in anal cancer patients treated with chemoradiotherapy: Rationale for immunotherapy. Oncoimmunology 6, e1288331
28405521   Curated Info

3

Helmke C, et al. (2016) Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8. Cell Res 26, 914-34
27325299   Curated Info

4

Rödel F, et al. (2016) Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy. Oncotarget 7, 53339-53349
27462786   Curated Info

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