Ser473
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.7
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser473  -  Akt1 (rat)

Site Information
RPHFPQFsYSASGTA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447855

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 35 , 58 ) , [32P] bio-synthetic labeling ( 153 , 176 ) , electrophoretic mobility shift ( 93 ) , immunoprecipitation ( 8 , 17 , 22 , 41 , 50 , 57 , 58 , 100 ) , mass spectrometry ( 58 ) , mass spectrometry (in vitro) ( 17 ) , microscopy-colocalization with upstream kinase ( 61 ) , mutation of modification site ( 3 , 17 , 50 , 80 , 103 , 111 , 186 , 188 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 8 , 9 , 10 , 11 , 12 , 13 , 15 , 17 , 19 , 20 , 22 , 27 , 28 , 29 , 31 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 55 , 56 , 57 , 58 , 59 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 110 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 8 , 9 , 10 , 11 , 12 , 13 , 15 , 17 , 19 , 20 , 22 , 27 , 28 , 29 , 31 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 55 , 56 , 57 , 58 , 59 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 80 , 81 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 101 , 102 , 103 , 104 , 105 , 106 , 112 , 113 , 115 , 117 , 118 , 119 , 120 , 122 , 124 , 127 , 128 , 130 , 132 , 133 , 136 , 138 , 140 , 143 , 145 , 146 , 147 , 148 , 150 , 151 , 153 , 154 , 155 , 156 , 158 , 159 , 160 , 161 , 163 , 164 , 165 , 167 , 168 , 170 , 171 , 172 , 173 , 174 , 176 , 179 , 181 , 182 , 186 , 187 , 188 )
Disease tissue studied:
Alzheimer's disease ( 22 , 40 ) , adrenal cancer ( 22 , 50 , 104 , 132 , 140 , 164 ) , pheochromocytoma ( 22 , 50 , 104 , 132 , 140 , 164 ) , brain cancer ( 4 , 102 , 188 ) , glioma ( 4 , 102 , 188 ) , breast cancer ( 59 , 85 ) , liver cancer ( 1 , 52 , 59 ) , lymphoma ( 155 ) , B cell lymphoma ( 155 ) , neuroblastoma ( 132 ) , pancreatic cancer ( 58 , 80 , 173 ) , pancreatic carcinoma ( 58 , 80 , 173 ) , colonic inflamation ( 11 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 35 , 43 , 162 ) , 'brain, hippocampus' ( 35 , 86 , 110 , 162 ) , 'brain, hypothalamus' ( 27 ) , 'brain, striatum' ( 43 ) , 'muscle, skeletal' ( 12 , 15 , 17 , 34 , 36 , 39 , 55 , 63 , 69 , 81 , 83 , 88 , 94 , 100 , 113 , 138 , 142 , 144 , 159 , 160 , 169 , 171 , 172 ) , 'muscle, smooth'-thoracic aorta ( 129 , 154 ) , 'neuron, bipolar' ( 150 ) , 'neuron, cerebellar granule' ( 9 ) , 'neuron, cerebellar granule'-brain ( 19 , 47 , 152 , 165 , 175 ) , 'neuron, cortical'-brain ( 3 , 38 , 41 , 74 , 145 , 156 ) , 'neuron, hippocampal'-brain ( 38 ) , 'neuron, rhombencephalic' ( 111 ) , 'neuron, sympathetic' ( 139 ) , 293 (epithelial) ( 52 , 98 ) , 293A (epithelial) ( 50 ) , 293T (epithelial) ( 17 ) , 32D (myeloid) ( 151 ) , 3T3 (fibroblast) ( 6 , 37 , 52 , 151 , 167 ) , 3T3 (fibroblast) [INSR (human)] ( 81 ) , 3T3-L1 (fibroblast) ( 52 , 81 , 151 ) , A10 (myoblast) ( 46 ) , A7r5 ('muscle, smooth') ( 158 ) , adipocyte ( 71 ) , adipocyte-adipose tissue ( 125 , 176 ) , adipose tissue ( 81 ) , aorta ( 148 ) , artery-heart ( 183 ) , astrocyte-'brain, cerebrum' ( 5 ) , astrocyte-'brain, striatum' ( 116 ) , beta-pancreas ( 31 ) , BHK-21 (fibroblast) ( 168 ) , brain ( 40 , 145 ) , C2C12 (myoblast) ( 62 ) , C6 (glial) ( 4 , 102 , 188 ) , cardiac ( 66 ) , CHO (fibroblast) [INSR (human)] ( 119 ) , COS (fibroblast) ( 80 ) , decidua ( 178 ) , endothelial-liver ( 13 ) , fibroblast-heart ( 93 , 146 ) , FRTL-5 (thyroid cell) ( 73 ) , granulosa ( 76 , 108 ) , H4IIe (hepatic) ( 1 , 52 , 153 ) , H9c2 (myoblast) ( 29 , 45 , 81 ) , heart ( 28 , 78 , 81 , 87 , 95 , 123 ) , hepatic stellate ( 115 ) , hepatocyte ( 151 ) , hepatocyte-liver ( 128 , 135 , 187 ) , HIRc (fibroblast) ( 163 ) , HUVEC (endothelial) ( 10 , 130 ) , IEC-18 (epithelial) ( 70 , 120 ) , IEC-18 (epithelial) [PIK3C2B (human)] ( 70 ) , IEC-6 (epithelial) ( 90 , 181 ) , INS-1 (pancreatic) ( 58 , 80 , 173 ) , IR938F (B lymphocyte) ( 155 ) , Jurkat (T lymphocyte) ( 155 ) , kidney ( 49 ) , L6 (myoblast) ( 37 , 44 , 48 , 96 , 143 ) , L6 (myoblast) [GLUT4 (rat)] ( 75 ) , L6E9 ( 184 ) , liver ( 27 , 59 , 81 , 92 , 99 , 101 , 127 , 136 ) , M059J (glial) ( 65 ) , mammary gland ( 59 ) , MDA-MB-468 (breast cell) ( 82 ) , MEF (fibroblast) ( 65 , 80 ) , mesangial ( 64 , 118 ) , microvessel endothelial-'brain, forebrain' ( 126 ) , MP48 (epithelial) ( 124 ) , MTLn3 (breast cell) ( 85 ) , muscle ( 106 ) , myoblast ( 51 ) , myocardium ( 91 ) , myocyte ( 121 ) , myocyte-heart ( 2 , 10 , 29 , 56 , 57 , 62 , 97 , 105 , 117 ) , neuron ( 50 ) , neuron-'brain, cerebellum' ( 132 , 186 ) , neuron-'brain, cerebral cortex' ( 84 ) , neuron-'brain, hippocampus' ( 3 , 122 , 166 ) , neutrophil-blood ( 20 ) , oligodendrocyte ( 179 , 188 ) , pancreatic acini ( 72 ) , PC-12 (chromaffin) ( 22 , 50 , 104 , 107 , 114 , 132 , 139 , 140 , 164 , 185 ) , penis ( 112 ) , RAEC (endothelial) ( 77 ) , Rat1 (fibroblast) ( 6 , 65 , 149 ) , Rat2 (fibroblast) ( 180 ) , RBL-2H3 (basophil) ( 182 ) , retina ( 147 ) , retinal ganglion ( 134 ) , RFPEC (endothelial) ( 130 ) , RIE (epithelial) ( 61 , 67 , 89 ) , RIE (epithelial) [PPAR-gamma (mouse)] ( 89 ) , RIN (epithelial) ( 133 ) , RM-4 (mesothelial) ( 141 ) , Schwann ( 42 ) , sertoli-testis ( 131 ) , SH-SY5Y (neural crest) ( 132 ) , SN4741 (neuron) ( 140 ) , spinal cord ( 11 ) , vascular smooth muscle cell ('muscle, smooth') ( 79 , 98 , 161 , 174 , 177 ) , vein ( 170 )

Upstream Regulation
Regulatory protein:
ADCY6 (mouse) ( 56 ) , AKAP12 (rat) ( 42 ) , Akt1 (rat) ( 157 ) , DISC1 (human) ( 84 ) , DYN1 (rat) ( 30 ) , EEA1 (rat) ( 30 ) , FAK (rat) ( 57 , 85 , 96 ) , GJA1 (rat) ( 4 ) , GRK2 (rat) ( 2 ) , HMOX1 (rat) ( 29 ) , ILK (human) ( 61 ) , ITGA5 (human) ( 67 ) , KRas (rat) ( 181 ) , LKB1 (human) ( 97 ) , Mer (rat) ( 187 ) , MKK4 (human) ( 105 ) , mTOR (rat) ( 77 ) , MYDGF (rat) ( 10 ) , OGT (human) ( 58 ) , PIK3C2A (human) ( 70 ) , PIK3CA (rat) ( 164 ) , PKCA (rat) ( 30 , 174 ) , PKCB (human) ( 174 ) , PKCD (mouse) ( 60 , 174 ) , PKCD (rat) ( 67 ) , RAC1 (rat) ( 75 ) , Raptor (rat) ( 77 ) , RICTOR (human) ( 77 ) , SHC1 (rat) ( 163 ) , SHIP-2 (human) ( 163 ) , SHP-2 (rat) ( 57 )
Putative in vivo kinases:
PKCA (rat) ( 130 ) , PKCE (mouse) ( 66 )
Kinases, in vitro:
PKCA (human) ( 130 )
Putative upstream phosphatases:
PPP2CA (rat) ( 176 )
Treatments:
1400W ( 44 ) , 2-AP ( 147 ) , 2-deoxyglucose ( 158 ) , 4-AP ( 3 ) , 4-HT ( 187 ) , 5-thio-glucose ( 158 ) , 6-OHDA ( 132 ) , 8-OH-DPAT ( 111 ) , 8-Rp-cAMP ( 56 ) , A304000 ( 55 ) , acadesine ( 83 , 108 , 169 ) , action_potential ( 19 ) , adrenalectomy ( 91 ) , adriamycin ( 85 ) , AEBSF ( 44 ) , AG1024 ( 46 , 79 ) , AG1296 ( 25 ) , AG1478 ( 25 , 93 , 120 , 140 , 181 ) , AG879 ( 150 ) , Akt-I-1,2 ( 19 ) , Akt_inhibitor_X ( 19 ) , alloxan ( 58 ) , amino_acid_starvation ( 37 ) , amino_acids ( 128 , 171 ) , angiopoietin-1 ( 117 ) , angiopoietin-2 ( 2 , 117 ) , angiotensin ( 98 , 120 ) , angiotensin_2 ( 30 , 44 , 46 , 146 ) , anisomycin ( 147 ) , anti-CD29 ( 141 ) , anti-CD53 ( 155 ) , anti-TNFalpha ( 159 ) , APV ( 19 ) , asbestos ( 141 ) , BADGP ( 58 ) , BBG ( 116 ) , BDNF ( 38 , 41 , 43 , 114 , 122 , 150 ) , berberine ( 36 ) , beta-amyloid_25-35 ( 22 ) , betacellulin ( 129 ) , bicuculline ( 3 ) , blood pressure ( 121 ) , bromocriptine ( 140 ) , bryostatin_1 ( 70 ) , buspirone ( 111 ) , C2-ceramide ( 75 , 176 ) , C5b-9 ( 179 ) , calyculin_A ( 70 , 153 ) , cAMP_analog ( 42 ) , cell_adhesion ( 61 , 149 ) , cell_detachment ( 103 ) , ceramide ( 143 ) , cGMP_analog ( 109 ) , cholecystokinin ( 72 ) , cisplatin ( 82 ) , Clostridium_lethal_toxin ( 182 ) , Clostridium_toxin_B ( 182 ) , CNQX ( 19 ) , colforsin ( 80 , 147 , 168 , 175 , 180 , 186 ) , compound_401 ( 65 ) , compound_C ( 54 ) , CORM-2 ( 29 ) , CPA ( 56 ) , CT98014 ( 69 ) , culturing_of_cells ( 74 , 101 ) , cyclic_stretch ( 57 ) , deoxygenation ( 5 ) , depolarization ( 175 ) , development ( 94 ) , dexamethasone ( 113 ) , DHC ( 176 ) , DiC8 ( 70 ) , DTG ( 50 ) , eflornithine ( 90 ) , EGF ( 22 , 53 , 82 , 93 , 107 , 140 , 173 , 180 ) , EGTA ( 116 ) , endothelin ( 46 , 49 ) , estradiol ( 71 ) , ethanol ( 99 , 111 , 123 ) , exenatide ( 31 ) , exercise ( 15 , 34 , 113 , 142 , 172 ) , fasting ( 39 , 106 ) , fibronectin ( 61 , 67 ) , fluid_shear_stress ( 112 ) , fMLP ( 20 ) , food deprivation ( 59 ) , furosemide ( 136 ) , GF109203X ( 143 , 174 ) , GLP-2 ( 168 ) , glucagon ( 128 ) , glucosamine ( 58 , 133 ) , glucose ( 79 , 157 , 158 , 173 ) , glucose_oxidase ( 75 ) , Go_6976 ( 174 ) , Go_6983 ( 174 ) , GRGDSP ( 136 , 141 ) , H-89 ( 56 , 73 ) , H2O2 ( 140 ) , haloperidol ( 50 ) , hemorrhage ( 127 ) , heregulin ( 188 ) , HGF ( 72 ) , hirudin ( 25 ) , hypertension ( 137 , 170 ) , hypoxia ( 77 , 105 , 110 , 158 , 185 ) , hypoxia/reoxygenation ( 105 , 135 ) , IGF-1 ( 21 , 45 , 62 , 88 , 108 , 114 , 130 , 157 , 165 , 173 , 175 , 184 , 186 , 188 ) , IGF-2 ( 45 ) , insulin ( 6 , 27 , 34 , 37 , 39 , 44 , 48 , 51 , 55 , 60 , 69 , 71 , 75 , 78 , 83 , 91 , 92 , 96 , 106 , 113 , 119 , 125 , 127 , 128 , 133 , 134 , 136 , 138 , 143 , 148 , 153 , 163 , 167 , 168 , 171 , 172 , 174 , 176 , 184 , 187 ) , Intralipid ( 88 ) , ipsapirone ( 111 ) , IR-A48 ( 6 ) , irbesartan ( 92 ) , ischemia ( 35 ) , ischemia/reperfusion ( 28 , 35 , 86 , 101 , 105 , 126 , 183 ) , iso-PPADS ( 116 ) , isoproterenol ( 93 ) , kainic_acid ( 162 , 166 ) , L-NAME ( 188 ) , laminin-1 ( 117 ) , laser_treatment ( 22 ) , leptin ( 27 , 148 ) , leucine ( 63 ) , liothyronine ( 54 , 124 ) , lithium ( 55 , 175 ) , LY294002 ( 11 , 25 , 38 , 43 , 50 , 61 , 65 , 70 , 72 , 82 , 98 , 101 , 103 , 104 , 107 , 110 , 118 , 124 , 130 , 134 , 140 , 145 , 146 , 147 , 153 , 156 , 158 , 161 , 168 , 172 , 174 , 177 , 181 , 184 ) , lysophosphatidylcholine ( 174 ) , meal feeding ( 87 , 100 ) , mechanical stress ( 94 , 116 , 118 ) , metoprolol ( 91 ) , MPP+ ( 47 ) , MRS_2179 ( 116 ) , muscle atrophy ( 144 ) , muscle contraction ( 39 ) , myricetin ( 44 ) , N-ethylmaleimede ( 161 ) , NAC ( 161 ) , neuregulin ( 145 ) , neurotrophin-3 ( 114 , 122 ) , neurotrophin-4 ( 114 ) , NGF ( 104 , 107 , 114 , 122 , 139 , 164 , 185 ) , NSC23766 ( 9 ) , obesity-inducing diet ( 34 ) , okadaic_acid ( 40 , 70 , 161 , 176 ) , oleic_acid ( 157 ) , osmotic_stress ( 153 ) , OXO ( 67 ) , p18_peptide ( 61 ) , paracetamol ( 102 ) , PCP ( 43 ) , PD169316 ( 138 ) , PD98059 ( 43 , 47 , 101 , 104 , 107 , 138 , 150 , 174 , 181 , 188 ) , PDGF ( 65 , 115 , 161 , 177 , 184 ) , phenylephrine ( 2 , 21 ) , phorbol_ester ( 60 , 70 , 174 ) , piclidenoson ( 95 ) , PIK90 ( 48 ) , PKI ( 56 ) , PKI-(14-22)amide ( 76 ) , pleiotrophin ( 62 ) , PP1 ( 124 ) , PP2 ( 31 , 46 , 57 , 61 , 90 , 124 , 136 , 140 ) , PP242 ( 48 ) , PP3 ( 46 ) , PP30 ( 48 ) , PPACK ( 25 ) , pramipexole ( 140 ) , PRL ( 178 ) , PTX ( 140 ) , PUGNAc ( 58 ) , rapamycin ( 37 , 38 , 48 , 65 , 70 , 77 , 115 , 188 ) , reelin ( 156 ) , refeeding ( 39 ) , resistin ( 28 ) , resveratrol ( 154 ) , RGDS ( 90 , 141 ) , Ro31-8220 ( 143 , 150 ) , rosiglitazone ( 167 ) , rottlerin ( 174 ) , RS5444 ( 89 ) , salicylate ( 138 ) , SB202190 ( 101 ) , SB203580 ( 101 , 188 ) , seliciclib ( 145 ) , sepsis ( 63 , 159 ) , serum ( 154 , 168 ) , sildenafil ( 121 ) , siRNA ( 96 ) , SMI11293 ( 41 ) , SN-50 ( 165 ) , SP600125 ( 105 ) , sulforaphane ( 1 ) , tauroursodeoxycholic_acid ( 152 ) , tautomycin ( 70 ) , TCH-116 ( 20 ) , testosterone ( 51 ) , TeTx ( 47 , 150 ) , TGF-alpha ( 173 ) , TGF-beta ( 64 , 76 ) , thrombin ( 25 , 93 , 177 ) , TNF ( 52 , 90 , 138 , 176 ) , TNP-OVA ( 182 ) , TPCK ( 165 ) , trauma ( 127 ) , tri-nitrobenzene_sulfonic_acid ( 11 ) , TSH ( 73 ) , U0126 ( 38 , 44 , 61 ) , UCN-01 ( 125 ) , urofollitropin ( 76 ) , V-100 ( 105 ) , V-150 ( 105 ) , vanadate ( 86 , 101 , 153 , 188 ) , VEGF ( 101 ) , vitronectin ( 117 ) , VX702 ( 105 ) , whey protein diet ( 15 ) , wortmannin ( 25 , 37 , 47 , 49 , 54 , 72 , 76 , 80 , 85 , 103 , 107 , 116 , 118 , 122 , 124 , 131 , 140 , 146 , 150 , 153 , 156 , 172 , 174 , 182 , 184 , 185 , 186 , 188 ) , Y27632 ( 61 )

Downstream Regulation
Effects of modification on Akt1:
activity, induced ( 116 , 121 , 141 ) , enzymatic activity, induced ( 78 , 79 , 177 , 187 ) , intracellular localization ( 56 , 178 ) , molecular association, regulation ( 177 )
Effects of modification on biological processes:
apoptosis, inhibited ( 188 ) , cell differentiation, altered ( 42 )
Induce interaction with:
RAF1 (rat) ( 177 )

Disease / Diagnostics Relevance
Relevant diseases:
major depressive disorder ( 84 )

References 

1

Axelsson AS, et al. (2017) Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Sci Transl Med 9
28615356   Curated Info

2

Schlegel P, et al. (2017) G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. PLoS One 12, e0182110
28759639   Curated Info

3

Wang J, et al. (2016) Serine 707 of APPL1 is Critical for the Synaptic NMDA Receptor-Mediated Akt Phosphorylation Signaling Pathway. Neurosci Bull 32, 323-30
27300007   Curated Info

4

González-Sánchez A, et al. (2016) Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes. Oncotarget 7, 49819-49833
27391443   Curated Info

5

Li X, et al. (2015) Inhibition of connexin43 improves functional recovery after ischemic brain injury in neonatal rats. Glia 63, 1553-67
25988944   Curated Info

6

Yunn NO, et al. (2015) Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation. Nucleic Acids Res 43, 7688-701
26245346   Curated Info

7

Kaneko YS, et al. (2015) Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells. J Neural Transm 122, 757-72
25504008   Curated Info

8

Kwon H, et al. (2015) Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation. Biochim Biophys Acta 1853, 1022-34
25667086   Curated Info

9

Stankiewicz TR, et al. (2015) Neuronal Apoptosis Induced by Selective Inhibition of Rac GTPase versus Global Suppression of Rho Family GTPases Is Mediated by Alterations in Distinct Mitogen-activated Protein Kinase Signaling Cascades. J Biol Chem 290, 9363-76
25666619   Curated Info

10

Korf-Klingebiel M, et al. (2015) Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. Nat Med 21, 140-9
25581518   Curated Info

11

Liu M, Kay JC, Shen S, Qiao LY (2015) Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCγ, PKC, and PI3K/Akt pathways during colitis. J Neuroinflammation 12, 151
26289587   Curated Info

12

Kain V, et al. (2015) Co-activator binding protein PIMT mediates TNF-α induced insulin resistance in skeletal muscle via the transcriptional down-regulation of MEF2A and GLUT4. Sci Rep 5, 15197
26468734   Curated Info

13

Liu S, Premont RT, Rockey DC (2014) Endothelial nitric-oxide synthase (eNOS) is activated through G-protein-coupled receptor kinase-interacting protein 1 (GIT1) tyrosine phosphorylation and Src protein. J Biol Chem 289, 18163-74
24764294   Curated Info

14

Hsieh MY, et al. (2014) The Inducible Nitric-oxide Synthase (iNOS)/Src Axis Mediates Toll-like Receptor 3 Tyrosine 759 Phosphorylation and Enhances Its Signal Transduction, Leading to Interferon-β Synthesis in Macrophages. J Biol Chem 289, 9208-20
24526685   Curated Info

15

Moura CS, et al. (2014) Whey protein hydrolysate enhances HSP90 but does not alter HSP60 and HSP25 in skeletal muscle of rats. PLoS One 9, e83437
24465380   Curated Info

16

Lin G, Brownsey RW, Macleod KM (2014) Complex regulation of PKCβ2 and PDK-1/AKT by ROCK2 in diabetic heart. PLoS One 9, e86520
24466133   Curated Info

17

Liu Y, et al. (2013) Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle. Biochem J 455, 195-206
23905686   Curated Info

18

Sharma N, Arias EB, Sequea DA, Cartee GD (2012) Preventing the calorie restriction-induced increase in insulin-stimulated Akt2 phosphorylation eliminates calorie restriction's effect on glucose uptake in skeletal muscle. Biochim Biophys Acta 1822, 1735-40
22846604   Curated Info

19

Smillie KJ, Cousin MA (2012) Akt/PKB controls the activity-dependent bulk endocytosis of synaptic vesicles. Traffic 13, 1004-11
22487004   Curated Info

20

Tsai YR, et al. (2012) The signaling mechanisms mediating the inhibitory effect of TCH-1116 on formyl peptide-stimulated superoxide anion generation in neutrophils. Eur J Pharmacol 682, 171-80
22510297   Curated Info

21

Bisping E, et al. (2012) Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy. J Biol Chem 287, 9827-34
22228770   Curated Info

22

Zhang H, Wu S, Xing D (2012) Inhibition of Aβ(25-35)-induced cell apoptosis by low-power-laser-irradiation (LPLI) through promoting Akt-dependent YAP cytoplasmic translocation. Cell Signal 24, 224-32
21945154   Curated Info

23

Chan TO, et al. (2011) Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity. Proc Natl Acad Sci U S A 108, E1120-7
22031698   Curated Info

24

Van de Velde S, Hogan MF, Montminy M (2011) mTOR links incretin signaling to HIF induction in pancreatic beta cells. Proc Natl Acad Sci U S A 108, 16876-82
21949366   Curated Info

25

Parrales A, López E, López-Colomé AM (2011) Thrombin activation of PI3K/PDK1/Akt signaling promotes cyclin D1 upregulation and RPE cell proliferation. Biochim Biophys Acta 1813, 1758-66
21736902   Curated Info

26

Angelone T, et al. (2011) Distinct signalling mechanisms are involved in the dissimilar myocardial and coronary effects elicited by quercetin and myricetin, two red wine flavonols. Nutr Metab Cardiovasc Dis 21, 362-71
20096547   Curated Info

27

Berthou F, et al. (2011) Chronic central leptin infusion differently modulates brain and liver insulin signaling. Mol Cell Endocrinol 337, 89-95
21320568   Curated Info

28

Smith CC, et al. (2011) Failure of the adipocytokine, resistin, to protect the heart from ischemia-reperfusion injury. J Cardiovasc Pharmacol Ther 16, 63-71
21183727   Curated Info

29

Lin HH, Lai SC, Chau LY (2011) Heme oxygenase-1/carbon monoxide induces vascular endothelial growth factor expression via p38 kinase-dependent activation of Sp1. J Biol Chem 286, 3829-38
21115498   Curated Info

30

Nazarewicz RR, et al. (2011) Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes. J Biol Chem 286, 2886-95
21097843   Curated Info

31

Mukai E, et al. (2011) Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner. Diabetes 60, 218-26
20978090   Curated Info

32

Li C, et al. (2011) Sensitization of glioma cells to tamoxifen-induced apoptosis by Pl3-kinase inhibitor through the GSK-3β/β-catenin signaling pathway. PLoS One 6, e27053
22046442   Curated Info

33

Trinko R, et al. (2011) Erk1/2 mediates leptin receptor signaling in the ventral tegmental area. PLoS One 6, e27180
22076135   Curated Info

34

Da Silva AS, et al. (2010) Exercise intensity, inflammatory signaling, and insulin resistance in obese rats. Med Sci Sports Exerc 42, 2180-8
20473230   Curated Info

35

Ayuso MI, et al. (2010) New hierarchical phosphorylation pathway of the translational repressor eIF4E-binding protein 1 (4E-BP1) in ischemia-reperfusion stress. J Biol Chem 285, 34355-63
20736160   Curated Info

36

Ma X, et al. (2010) Berberine-induced activation of 5'-adenosine monophosphate-activated protein kinase and glucose transport in rat skeletal muscles. Metabolism 59, 1619-27
20423742   Curated Info

37

Nascimento EB, et al. (2010) Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1. Cell Signal 22, 961-7
20138985   Curated Info

38

Zhou X, et al. (2010) Intracellular calcium and calmodulin link brain-derived neurotrophic factor to p70S6 kinase phosphorylation and dendritic protein synthesis. J Neurosci Res 88, 1420-32
20029971   Curated Info

39

Lai YC, Zarrinpashneh E, Jensen J (2010) Additive effect of contraction and insulin on glucose uptake and glycogen synthase in muscle with different glycogen contents. J Appl Physiol 108, 1106-15
20185632   Curated Info

40

Qian W, et al. (2010) PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. J Alzheimers Dis 19, 1221-9
20308788   Curated Info

41

Huang YZ, McNamara JO (2010) Mutual regulation of Src family kinases and the neurotrophin receptor TrkB. J Biol Chem 285, 8207-17
20064930   Curated Info

42

Ji Y, et al. (2010) SSeCKS is a suppressor in Schwann cell differentiation and myelination. Neurochem Res 35, 219-26
19757038   Curated Info

43

Xia Y, et al. (2010) Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways. Neuropharmacology 58, 330-6
19887077   Curated Info

44

Csibi A, Communi D, Müller N, Bottari SP (2010) Angiotensin II inhibits insulin-stimulated GLUT4 translocation and Akt activation through tyrosine nitration-dependent mechanisms. PLoS One 5, e10070
20383279   Curated Info

45

Chen RJ, et al. (2009) Leu27IGF2 plays an opposite role to IGF1 to induce H9c2 cardiomyoblast cell apoptosis via Galphaq signaling. J Mol Endocrinol 43, 221-30
19556392   Curated Info

46

Bouallegue A, Vardatsikos G, Srivastava AK (2009) Role of insulin-like growth factor 1 receptor and c-Src in endothelin-1- and angiotensin II-induced PKB phosphorylation, and hypertrophic and proliferative responses in vascular smooth muscle cells. Can J Physiol Pharmacol 87, 1009-18
20029537   Curated Info

47

Chaïb-Oukadour I, et al. (2009) Tetanus toxin H(C) fragment reduces neuronal MPP+ toxicity. Mol Cell Neurosci 41, 297-303
19344769   Curated Info

48

Feldman ME, et al. (2009) Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 7, e38
19209957   Curated Info

49

Herrera M, Hong NJ, Ortiz PA, Garvin JL (2009) Endothelin-1 inhibits thick ascending limb transport via Akt-stimulated nitric oxide production. J Biol Chem 284, 1454-60
19033447   Curated Info

50

Wei Z, et al. (2009) Haloperidol disrupts Akt signalling to reveal a phosphorylation-dependent regulation of pro-apoptotic Bcl-XS function. Cell Signal 21, 161-8
18951975   Curated Info

51

Allemand MC, et al. (2009) Effect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes--a potential model for PCOS-related insulin resistance. PLoS One 4, e4274
19169352   Curated Info

52

Zhang J, et al. (2008) S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. J Biol Chem 283, 35375-82
18952604   Curated Info

53

Philippar U, et al. (2008) A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell 15, 813-28
19081071   Curated Info

54

de Lange P, et al. (2008) Rapid activation by 3,5,3'-L-triiodothyronine of adenosine 5'-monophosphate-activated protein kinase/acetyl-coenzyme a carboxylase and akt/protein kinase B signaling pathways: relation to changes in fuel metabolism and myosin heavy-chain protein content in rat gastrocnemius muscle in vivo. Endocrinology 149, 6462-70
18703632   Curated Info

55

Macko AR, Beneze AN, Teachey MK, Henriksen EJ (2008) Roles of insulin signalling and p38 MAPK in the activation by lithium of glucose transport in insulin-resistant rat skeletal muscle. Arch Physiol Biochem 114, 331-9
19023684   Curated Info

56

Gao MH, et al. (2008) Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes. J Biol Chem 283, 33527-35
18838385   Curated Info

57

Marin TM, et al. (2008) Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/Src and mTOR pathways. Circ Res 103, 813-24
18757826   Curated Info

58

Kang ES, et al. (2008) O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells. Exp Cell Res 314, 2238-48
18570920   Curated Info

59

Jiang W, Zhu Z, Thompson HJ (2008) Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver. Cancer Res 68, 5492-9
18593953   Curated Info

60

Waraich RS, et al. (2008) Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells. J Biol Chem 283, 11226-33
18285345   Curated Info

61

Kim YB, et al. (2008) Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complex. J Biol Chem 283, 10089-96
18252715   Curated Info

62

Li J, et al. (2007) The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity. J Biol Chem 282, 34984-93
17925408   Curated Info

63

Vary TC (2007) Acute oral leucine administration stimulates protein synthesis during chronic sepsis through enhanced association of eukaryotic initiation factor 4G with eukaryotic initiation factor 4E in rats. J Nutr 137, 2074-9
17709445   Curated Info

64

Kim SM, et al. (2007) TGF-beta1-induced PINCH-1-ILK-alpha-parvin complex formation regulates mesangial cell proliferation and hypertrophy. Exp Mol Med 39, 514-23
17934340   Curated Info

65

Ballou LM, et al. (2007) Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem 282, 24463-70
17562705   Curated Info

66

Rybin VO, et al. (2007) Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytes. J Biol Chem 282, 23631-8
17569658   Curated Info

67

Oh MA, et al. (2007) PKCdelta and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin alpha5 but not its tailless mutant. J Cell Sci 120, 2717-30
17646675   Curated Info

68

Tang CH, et al. (2007) Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J Immunol 179, 1292-302
17617622   Curated Info

69

Henriksen EJ, Teachey MK (2007) Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty rats. Metabolism 56, 931-8
17570255   Curated Info

70

Guan L, et al. (2007) Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells. J Biol Chem 282, 14213-25
17360714   Curated Info

71

Jaubert AM, et al. (2007) Nongenomic estrogen effects on nitric oxide synthase activity in rat adipocytes. Endocrinology 148, 2444-52
17303666   Curated Info

72

Berna MJ, et al. (2007) CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathways. Biochim Biophys Acta 1773, 483-501
17306383   Curated Info

73

De Gregorio G, et al. (2007) The p85 regulatory subunit of PI3K mediates TSH-cAMP-PKA growth and survival signals. Oncogene 26, 2039-47
17043656   Curated Info

74

Liang MH, Chuang DM (2007) Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. J Biol Chem 282, 3904-17
17148450   Curated Info

75

JeBailey L, et al. (2007) Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells. Diabetes 56, 394-403
17259384   Curated Info

76

Chen YJ, et al. (2007) Interplay of PI3K and cAMP/PKA signaling, and rapamycin-hypersensitivity in TGFbeta1 enhancement of FSH-stimulated steroidogenesis in rat ovarian granulosa cells. J Endocrinol 192, 405-19
17283241   Curated Info

77

Li W, et al. (2007) Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2. Circ Res 100, 79-87
17110594   Curated Info

78

Mouton V, et al. (2007) Evaluation of the role of protein kinase Czeta in insulin-induced heart 6-phosphofructo-2-kinase activation. Cell Signal 19, 52-61
16829026   Curated Info

79

Li M, Chiu JF, Mossman BT, Fukagawa NK (2006) Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats. J Biol Chem 281, 40429-39
17079231   Curated Info

80

Hurley RL, et al. (2006) Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP. J Biol Chem 281, 36662-72
17023420   Curated Info

81

Nascimento EB, et al. (2006) Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats. Diabetes 55, 3221-8
17130464   Curated Info

82

Winograd-Katz SE, Levitzki A (2006) Cisplatin induces PKB/Akt activation and p38(MAPK) phosphorylation of the EGF receptor. Oncogene 25, 7381-90
16785992   Curated Info

83

Fediuc S, Gaidhu MP, Ceddia RB (2006) Inhibition of insulin-stimulated glycogen synthesis by 5-aminoimidasole-4-carboxamide-1-beta-d-ribofuranoside-induced adenosine 5'-monophosphate-activated protein kinase activation: interactions with Akt, glycogen synthase kinase 3-3alpha/beta, and glycogen synthase in isolated rat soleus muscle. Endocrinology 147, 5170-7
16873531   Curated Info

84

Hashimoto R, et al. (2006) Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet 15, 3024-33
16959794   Curated Info

85

van Nimwegen MJ, et al. (2006) Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells. Mol Pharmacol 70, 1330-9
16825486   Curated Info

86

Zhang QG, et al. (2006) Akt inhibits MLK3/JNK3 signaling by inactivating Rac1: a protective mechanism against ischemic brain injury. J Neurochem 98, 1886-98
16831194   Curated Info

87

Vary TC, Lynch CJ (2006) Meal feeding stimulates phosphorylation of multiple effector proteins regulating protein synthetic processes in rat hearts. J Nutr 136, 2284-90
16920842   Curated Info

88

Lang CH (2006) Elevated plasma free fatty acids decrease basal protein synthesis, but not the anabolic effect of leucine, in skeletal muscle. Am J Physiol Endocrinol Metab 291, E666-74
16684854   Curated Info

89

Chen L, et al. (2006) Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2. J Biol Chem 281, 24575-87
16815847   Curated Info

90

Bhattacharya S, Ray RM, Johnson LR (2006) Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. Biochem J 397, 437-47
16669788   Curated Info

91

Samuelsson AM, et al. (2006) Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways. Am J Physiol Heart Circ Physiol 291, H787-96
16565309   Curated Info

92

Muñoz MC, et al. (2006) Irbesartan restores the in-vivo insulin signaling pathway leading to Akt activation in obese Zucker rats. J Hypertens 24, 1607-17
16877964   Curated Info

93

Obreztchikova M, et al. (2006) Distinct signaling functions for Shc isoforms in the heart. J Biol Chem 281, 20197-204
16699171   Curated Info

94

Thomson DM, Gordon SE (2006) Impaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscle. J Physiol 574, 291-305
16627569   Curated Info

95

Park SS, et al. (2006) N6-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide confers cardioprotection at reperfusion by inhibiting mitochondrial permeability transition pore opening via glycogen synthase kinase 3 beta. J Pharmacol Exp Ther 318, 124-31
16611852   Curated Info

96

Huang D, Khoe M, Ilic D, Bryer-Ash M (2006) Reduced expression of focal adhesion kinase disrupts insulin action in skeletal muscle cells. Endocrinology 147, 3333-43
16574795   Curated Info

97

Soltys CL, Kovacic S, Dyck JR (2006) Activation of cardiac AMP-activated protein kinase by LKB1 expression or chemical hypoxia is blunted by increased Akt activity. Am J Physiol Heart Circ Physiol 290, H2472-9
16428351   Curated Info

98

Douillette A, et al. (2006) The proinflammatory actions of angiotensin II are dependent on p65 phosphorylation by the IkappaB kinase complex. J Biol Chem 281, 13275-84
16513650   Curated Info

99

He L, et al. (2006) Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation. J Biol Chem 281, 11126-34
16452480   Curated Info

100

Vary TC, Lynch CJ (2006) Meal feeding enhances formation of eIF4F in skeletal muscle: role of increased eIF4E availability and eIF4G phosphorylation. Am J Physiol Endocrinol Metab 290, E631-42
16263769   Curated Info

101

Ohi N, et al. (2006) Maintenance of Bad phosphorylation prevents apoptosis of rat hepatic sinusoidal endothelial cells in vitro and in vivo. Am J Pathol 168, 1097-106
16565486   Curated Info

102

Lee YS, et al. (2006) Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen. J Pharmacol Exp Ther 317, 202-8
16330492   Curated Info

103

Toruner M, et al. (2006) Antianoikis effect of nuclear factor-kappaB through up-regulated expression of osteoprotegerin, BCL-2, and IAP-1. J Biol Chem 281, 8686-96
16407217   Curated Info

104

Chen YL, Law PY, Loh HH (2006) Sustained activation of phosphatidylinositol 3-kinase/Akt/nuclear factor kappaB signaling mediates G protein-coupled delta-opioid receptor gene expression. J Biol Chem 281, 3067-74
16316997   Curated Info

105

Shao Z, et al. (2006) c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo. Circ Res 98, 111-8
16306447   Curated Info

106

Jensen J, et al. (2006) Muscle glycogen inharmoniously regulates glycogen synthase activity, glucose uptake, and proximal insulin signaling. Am J Physiol Endocrinol Metab 290, E154-E162
16118249   Curated Info

107

Hu Y, et al. (2005) Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation. EMBO J 24, 3543-54
16177823   Curated Info

108

Tosca L, et al. (2005) Adenosine 5'-monophosphate-activated protein kinase regulates progesterone secretion in rat granulosa cells. Endocrinology 146, 4500-13
16020477   Curated Info

109

Zhao X, et al. (2005) Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3. J Biol Chem 280, 32683-92
16055922   Curated Info

110

Klein JB, et al. (2005) Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins. J Biol Chem 280, 31870-81
16027165   Curated Info

111

Druse M, Tajuddin NF, Gillespie RA, Le P (2005) Signaling pathways involved with serotonin1A agonist-mediated neuroprotection against ethanol-induced apoptosis of fetal rhombencephalic neurons. Brain Res Dev Brain Res 159, 18-28
16081165   Curated Info

112

Musicki B, Kramer MF, Becker RE, Burnett AL (2005) Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction. Proc Natl Acad Sci U S A 102, 11870-5
16085713   Curated Info

113

Ruzzin J, Jensen J (2005) Contraction activates glucose uptake and glycogen synthase normally in muscles from dexamethasone-treated rats. Am J Physiol Endocrinol Metab 289, E241-50
15741240   Curated Info

114

Gan L, et al. (2005) Nuclear/cytoplasmic shuttling of the transcription factor FoxO1 is regulated by neurotrophic factors. J Neurochem 93, 1209-19
15934941   Curated Info

115

Gäbele E, et al. (2005) The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem 280, 13374-82
15677443   Curated Info

116

Neary JT, Kang Y, Tran M, Feld J (2005) Traumatic injury activates protein kinase B/Akt in cultured astrocytes: role of extracellular ATP and P2 purinergic receptors. J Neurotrauma 22, 491-500
15853465   Curated Info

117

Dallabrida SM, et al. (2005) Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins. Circ Res 96, e8-24
15692086   Curated Info

118

Krepinsky JC, et al. (2005) Stretch-induced Raf-1 activation in mesangial cells requires actin cytoskeletal integrity. Cell Signal 17, 311-20
15567062   Curated Info

119

Liberman Z, Eldar-Finkelman H (2005) Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling. J Biol Chem 280, 4422-8
15574412   Curated Info

120

Chiu T, Santiskulvong C, Rozengurt E (2005) EGF receptor transactivation mediates ANG II-stimulated mitogenesis in intestinal epithelial cells through the PI3-kinase/Akt/mTOR/p70S6K1 signaling pathway. Am J Physiol Gastrointest Liver Physiol 288, G182-94
15358595   Curated Info

121

Takimoto E, et al. (2005) Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Nat Med 11, 214-22
15665834   Curated Info

122

Yoshimura T, et al. (2005) GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell 120, 137-49
15652488   Curated Info

123

Vary TC, Deiter G, Goodman SA (2005) Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling. Am J Physiol Heart Circ Physiol 288, H121-8
15388509   Curated Info

124

Lei J, Mariash CN, Ingbar DH (2004) 3,3',5-Triiodo-L-thyronine up-regulation of Na,K-ATPase activity and cell surface expression in alveolar epithelial cells is Src kinase- and phosphoinositide 3-kinase-dependent. J Biol Chem 279, 47589-600
15342623   Curated Info

125

Kondapaka SB, et al. (2004) 7-hydroxystaurosporine (UCN-01) inhibition of Akt Thr308 but not Ser473 phosphorylation: a basis for decreased insulin-stimulated glucose transport. Clin Cancer Res 10, 7192-8
15534092   Curated Info

126

Osuka K, et al. (2004) Modification of endothelial NO synthase through protein phosphorylation after forebrain cerebral ischemia/reperfusion. Stroke 35, 2582-6
15375304   Curated Info

127

Ma Y, et al. (2004) Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha. Endocrinology 145, 5168-76
15297437   Curated Info

128

Mothe-Satney I, et al. (2004) In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids. J Biol Chem 279, 42628-37
15292249   Curated Info

129

Mifune M, et al. (2004) Signal transduction of betacellulin in growth and migration of vascular smooth muscle cells. Am J Physiol Cell Physiol 287, C807-13
15163624   Curated Info

130

Partovian C, Simons M (2004) Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Calpha in endothelial cells. Cell Signal 16, 951-7
15157674   Curated Info

131

Fix C, Jordan C, Cano P, Walker WH (2004) Testosterone activates mitogen-activated protein kinase and the cAMP response element binding protein transcription factor in Sertoli cells. Proc Natl Acad Sci U S A 101, 10919-24
15263086   Curated Info

132

Chen G, et al. (2004) Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal death. FASEB J 18, 1162-4
15132987   Curated Info

133

Andreozzi F, et al. (2004) Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells. Endocrinology 145, 2845-57
15001544   Curated Info

134

Rajala RV, et al. (2004) Interaction of the retinal insulin receptor beta-subunit with the p85 subunit of phosphoinositide 3-kinase. Biochemistry 43, 5637-50
15134438   Curated Info

135

Terui K, et al. (2004) Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction. Biochem J 380, 203-9
14984365   Curated Info

136

Schliess F, et al. (2004) Involvement of integrins and Src in insulin signaling toward autophagic proteolysis in rat liver. J Biol Chem 279, 21294-301
14985360   Curated Info

137

Sasser JM, et al. (2004) Reduced NOS3 phosphorylation mediates reduced NO/cGMP signaling in mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats. Hypertension 43, 1080-5
14993198   Curated Info

138

de Alvaro C, Teruel T, Hernandez R, Lorenzo M (2004) Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. J Biol Chem 279, 17070-8
14764603   Curated Info

139

Marsh HN, et al. (2003) SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase. J Cell Biol 163, 999-1010
14662744   Curated Info

140

Nair VD, Sealfon SC (2003) Agonist-specific transactivation of phosphoinositide 3-kinase signaling pathway mediated by the dopamine D2 receptor. J Biol Chem 278, 47053-61
12970364   Curated Info

141

Berken A, Abel J, Unfried K (2003) beta1-integrin mediates asbestos-induced phosphorylation of AKT and ERK1/2 in a rat pleural mesothelial cell line. Oncogene 22, 8524-8
14627993   Curated Info

142

Bolster DR, et al. (2003) Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle. J Physiol 553, 213-20
12937293   Curated Info

143

Powell DJ, Hajduch E, Kular G, Hundal HS (2003) Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. Mol Cell Biol 23, 7794-808
14560023   Curated Info

144

Hilder TL, et al. (2003) Phosphorylation of insulin receptor substrate-1 serine 307 correlates with JNK activity in atrophic skeletal muscle. FEBS Lett 553, 63-7
14550547   Curated Info

145

Li BS, et al. (2003) Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. J Biol Chem 278, 35702-9
12824184   Curated Info

146

Tian B, Liu J, Bitterman P, Bache RJ (2003) Angiotensin II modulates nitric oxide-induced cardiac fibroblast apoptosis by activation of AKT/PKB. Am J Physiol Heart Circ Physiol 285, H1105-12
12763754   Curated Info

147

Campos CB, Bédard PA, Linden R (2003) Selective involvement of the PI3K/PKB/bad pathway in retinal cell death. J Neurobiol 56, 171-7
12838582   Curated Info

148

Vecchione C, et al. (2003) Cooperation between insulin and leptin in the modulation of vascular tone. Hypertension 42, 166-70
12835332   Curated Info

149

Sawada S, et al. (2003) The tetraspanin CD151 functions as a negative regulator in the adhesion-dependent activation of Ras. J Biol Chem 278, 26323-6
12782641   Curated Info

150

Gil C, Chaib-Oukadour I, Aguilera J (2003) C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neurons. Biochem J 373, 613-20
12710887   Curated Info

151

Sakoda H, et al. (2003) Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity. J Biol Chem 278, 25802-7
12734207   Curated Info

152

Rodrigues CM, et al. (2003) Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. Proc Natl Acad Sci U S A 100, 6087-92
12721362   Curated Info

153

Lornejad-Schäfer MR, et al. (2003) Osmotic regulation of insulin-induced mitogen-activated protein kinase phosphatase (MKP-1) expression in H4IIE rat hepatoma cells. Biochem J 371, 609-19
12529177   Curated Info

154

Haider UG, et al. (2003) Resveratrol increases serine15-phosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth muscle cells. Mol Pharmacol 63, 925-32
12644594   Curated Info

155

Yunta M, Lazo PA (2003) Apoptosis protection and survival signal by the CD53 tetraspanin antigen. Oncogene 22, 1219-24
12606948   Curated Info

156

Beffert U, et al. (2002) Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. J Biol Chem 277, 49958-64
12376533   Curated Info

157

Wrede CE, et al. (2002) Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem 277, 49676-84
12393870   Curated Info

158

Loberg RD, Vesely E, Brosius FC (2002) Enhanced glycogen synthase kinase-3beta activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolism. J Biol Chem 277, 41667-73
12200436   Curated Info

159

Vary TC, Deiter G, Kimball SR (2002) Phosphorylation of eukaryotic initiation factor eIF2Bepsilon in skeletal muscle during sepsis. Am J Physiol Endocrinol Metab 283, E1032-9
12376332   Curated Info

160

Kumar V, Frost RA, Lang CH (2002) Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle. Am J Physiol Endocrinol Metab 283, E917-28
12376318   Curated Info

161

Yellaturu CR, Bhanoori M, Neeli I, Rao GN (2002) N-Ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A. J Biol Chem 277, 40148-55
12171932   Curated Info

162

Henshall DC, et al. (2002) Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death. J Neurosci 22, 8458-65
12351720   Curated Info

163

Ishihara H, et al. (2002) Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors. Mol Endocrinol 16, 2371-81
12351701   Curated Info

164

Cheng HC, Shih HM, Chern Y (2002) Essential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage of the MAPK cascade. J Biol Chem 277, 33930-42
12114502   Curated Info

165

Meng F, Liu L, Chin PC, D'Mello SR (2002) Akt is a downstream target of NF-kappa B. J Biol Chem 277, 29674-80
12052823   Curated Info

166

Kim AH, et al. (2002) Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron 35, 697-709
12194869   Curated Info

167

Jiang G, et al. (2002) Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPARgamma agonists. Diabetes 51, 2412-9
12145152   Curated Info

168

Yusta B, Estall J, Drucker DJ (2002) Glucagon-like peptide-2 receptor activation engages bad and glycogen synthase kinase-3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of phosphatidylinositol 3-kinase. J Biol Chem 277, 24896-906
11978789   Curated Info

169

Bolster DR, Crozier SJ, Kimball SR, Jefferson LS (2002) AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem 277, 23977-80
11997383   Curated Info

170

Iwakiri Y, et al. (2002) Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension. Am J Physiol Heart Circ Physiol 282, H2084-90
12003815   Curated Info

171

Reynolds TH, Bodine SC, Lawrence JC (2002) Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. J Biol Chem 277, 17657-62
11884412   Curated Info

172

Sakamoto K, Hirshman MF, Aschenbach WG, Goodyear LJ (2002) Contraction regulation of Akt in rat skeletal muscle. J Biol Chem 277, 11910-7
11809761   Curated Info

173

Lingohr MK, et al. (2002) Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation. Diabetes 51, 966-76
11916914   Curated Info

174

Motley ED, et al. (2002) Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein kinase C-alpha in vascular smooth muscle cells. Hypertension 39, 508-12
11882599   Curated Info

175

Kumari S, et al. (2001) Distinct phosphorylation patterns underlie Akt activation by different survival factors in neurons. Brain Res Mol Brain Res 96, 157-62
11731021   Curated Info

176

Teruel T, Hernandez R, Lorenzo M (2001) Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. Diabetes 50, 2563-71
11679435   Curated Info

177

Reusch HP, et al. (2001) Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells. J Biol Chem 276, 33630-7
11443134   Curated Info

178

Tessier C, et al. (2001) PRL antiapoptotic effect in the rat decidua involves the PI3K/protein kinase B-mediated inhibition of caspase-3 activity. Endocrinology 142, 4086-94
11517188   Curated Info

179

Soane L, et al. (2001) C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway. J Immunol 167, 2305-11
11490019   Curated Info

180

Kim S, et al. (2001) Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1. J Biol Chem 276, 12864-70
11278269   Curated Info

181

Sheng H, Shao J, Dubois RN (2001) K-Ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B1. Cancer Res 61, 2670-5
11289146   Curated Info

182

Djouder N, et al. (2001) Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells. J Immunol 166, 1627-34
11160204   Curated Info

183

Janelidze S, Hu BR, Siesjö P, Siesjö BK (2001) Alterations of Akt1 (PKBalpha) and p70(S6K) in transient focal ischemia. Neurobiol Dis 8, 147-54
11162248   Curated Info

184

Adi S, Wu NY, Rosenthal SM (2001) Growth factor-stimulated phosphorylation of Akt and p70(S6K) is differentially inhibited by LY294002 and Wortmannin. Endocrinology 142, 498-501
11145615   Curated Info

185

Beitner-Johnson D, Rust RT, Hsieh TC, Millhorn DE (2001) Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells. Cell Signal 13, 23-7
11257444   Curated Info

186

Li M, et al. (2000) Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta. Mol Cell Biol 20, 9356-63
11094086   Curated Info

187

Iynedjian PB, Roth RA, Fleischmann M, Gjinovci A (2000) Activation of protein kinase B/cAkt in hepatocytes is sufficient for the induction of expression of the gene encoding glucokinase. Biochem J 351 Pt 3, 621-7
11042116   Curated Info

188

Flores AI, et al. (2000) Akt-mediated survival of oligodendrocytes induced by neuregulins. J Neurosci 20, 7622-30
11027222   Curated Info