Ser473

Site Information
RPHFPQFsYSASGTA SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 447855

In vivo Characterization
Methods used to characterize site in vivo:	2D analysis ( 78 , 104 ) , [32P] bio-synthetic labeling ( 201 , 224 ) , electrophoretic mobility shift ( 140 ) , immunoassay ( 8 , 16 , 27 , 29 , 57 , 94 ) , immunoprecipitation ( 45 , 46 , 60 , 61 , 65 , 84 , 96 , 103 , 104 , 147 ) , mass spectrometry ( 104 ) , mass spectrometry (in vitro) ( 60 ) , microscopy-colocalization with upstream kinase ( 107 ) , mutation of modification site ( 41 , 60 , 96 , 127 , 150 , 158 , 234 , 236 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 38 , 39 , 40 , 41 , 42 , 43 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 54 , 55 , 56 , 57 , 58 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 101 , 102 , 103 , 104 , 105 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 157 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 235 , 236 , 237 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 38 , 39 , 40 , 41 , 42 , 43 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 54 , 55 , 56 , 57 , 58 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 101 , 102 , 103 , 104 , 105 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 127 , 128 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 148 , 149 , 150 , 151 , 152 , 153 , 159 , 160 , 162 , 164 , 165 , 166 , 167 , 169 , 170 , 172 , 175 , 176 , 178 , 180 , 181 , 184 , 186 , 188 , 191 , 193 , 194 , 195 , 196 , 198 , 199 , 201 , 202 , 203 , 204 , 206 , 207 , 208 , 209 , 211 , 212 , 213 , 215 , 216 , 218 , 219 , 220 , 221 , 222 , 224 , 227 , 229 , 230 , 234 , 235 , 236 , 237 )
Disease tissue studied:	Alzheimer's disease ( 65 , 83 ) , adrenal cancer ( 22 , 45 , 65 , 96 , 151 , 180 , 188 , 212 ) , pheochromocytoma ( 22 , 45 , 65 , 96 , 151 , 180 , 188 , 212 ) , brain cancer ( 42 , 75 , 149 , 236 ) , glioma ( 42 , 75 , 149 , 236 ) , breast cancer ( 105 , 132 ) , liver cancer ( 39 , 98 , 105 ) , lymphoma ( 203 ) , B cell lymphoma ( 203 ) , neuroblastoma ( 180 ) , pancreatic cancer ( 67 , 104 , 127 , 221 ) , pancreatic carcinoma ( 67 , 104 , 127 , 221 ) , colonic inflamation ( 50 ) , polycystic ovary syndrome ( 3 )
Relevant cell line - cell type - tissue:	'brain, cerebral cortex' ( 27 , 30 , 57 , 78 , 86 , 210 ) , 'brain, frontal cortex' ( 10 ) , 'brain, hippocampus' ( 16 , 19 , 25 , 78 , 133 , 157 , 210 ) , 'brain, hippocampus, CA1 region' ( 16 , 57 ) , 'brain, hypothalamus' ( 70 , 91 ) , 'brain, striatum' ( 86 ) , 'brain, ventral tegmental area' ( 91 ) , 'heart, ventricle' ( 69 ) , 'muscle, skeletal' ( 4 , 18 , 20 , 34 , 51 , 58 , 60 , 61 , 77 , 79 , 82 , 101 , 110 , 116 , 128 , 130 , 135 , 141 , 147 , 160 , 186 , 190 , 192 , 207 , 208 , 217 , 219 , 220 ) , 'muscle, smooth'-thoracic aorta ( 177 , 202 ) , 'neuron, bipolar' ( 198 ) , 'neuron, cerebellar granule' ( 47 ) , 'neuron, cerebellar granule'-brain ( 62 , 90 , 200 , 213 , 223 ) , 'neuron, cortical'-brain ( 41 , 81 , 84 , 121 , 193 , 204 ) , 'neuron, dorsal root ganglion' ( 29 ) , 'neuron, hippocampal'-brain ( 48 , 81 ) , 'neuron, rhombencephalic' ( 158 ) , 'neuron, sympathetic' ( 187 ) , 'neuron, ventral tegmental'-brain ( 76 ) , 293 (epithelial) ( 98 , 145 ) , 32D (myeloid) ( 199 ) , 3T3 (fibroblast) [INSR (human)] ( 128 ) , 3T3 (fibroblast) ( 44 , 80 , 98 , 199 , 215 ) , 3T3-L1 (fibroblast) ( 98 , 128 , 199 ) , A10 (myoblast) ( 89 ) , A7r5 ('muscle, smooth') ( 206 ) , adipocyte ( 118 ) , adipocyte-adipose tissue ( 173 , 224 ) , adipose tissue ( 12 , 128 ) , aorta ( 196 ) , artery-heart ( 231 ) , astrocyte ( 8 , 9 , 16 ) , astrocyte-'brain, cerebrum' ( 43 ) , astrocyte-'brain, striatum' ( 163 ) , beta-pancreas ( 74 ) , BHK-21 (fibroblast) ( 216 ) , brain ( 21 , 83 , 193 ) , C2C12 (myoblast) ( 109 ) , C6 (glial) ( 42 , 75 , 149 , 236 ) , cardiac ( 113 ) , CHO (fibroblast) [INSR (human)] ( 166 ) , chondrocyte ( 56 ) , COS (fibroblast) ( 127 ) , decidua ( 226 ) , endometrium ( 3 ) , endothelial-liver ( 52 ) , fibroblast-heart ( 140 , 194 ) , FRTL-5 (thyroid cell) ( 120 ) , granulosa ( 123 , 155 ) , H4IIe (hepatic) ( 39 , 98 , 201 ) , H9c2 (myoblast) ( 1 , 24 , 33 , 66 , 72 , 88 , 128 ) , heart ( 36 , 71 , 125 , 128 , 134 , 142 , 169 , 171 ) , HEK293-A (epithelial) ( 96 ) , HEK293T (epithelial) ( 60 ) , hepatic stellate ( 162 ) , hepatocyte ( 199 ) , hepatocyte-liver ( 176 , 183 , 235 ) , HESCs (endometrial) ( 3 ) , HIRc (fibroblast) ( 211 ) , HUVEC (endothelial) ( 49 , 69 , 178 ) , IEC-18 (epithelial) [PIK3C2B (human)] ( 117 ) , IEC-18 (epithelial) ( 117 , 167 ) , IEC-6 (epithelial) ( 137 , 229 ) , INS-1 (pancreatic) ( 67 , 104 , 127 , 221 ) , IR983F (B lymphocyte) ( 203 ) , Jurkat (T lymphocyte) ( 203 ) , kidney ( 7 , 11 , 26 , 95 ) , L6 (myoblast) [GLUT4 (rat)] ( 122 ) , L6 (myoblast) ( 13 , 23 , 35 , 80 , 87 , 92 , 143 , 191 ) , L6E9 ( 232 ) , liver ( 28 , 54 , 70 , 105 , 128 , 139 , 146 , 148 , 175 , 184 ) , lung ( 17 , 32 ) , M059J (glial) ( 112 ) , mammary gland ( 105 ) , MDA-MB-468 (breast cell) ( 129 ) , MEF (fibroblast) ( 112 , 127 ) , mesangial ( 111 , 165 ) , microglia ( 115 ) , microvessel endothelial-'brain, forebrain' ( 174 ) , MP48 (epithelial) ( 172 ) , MTLn3 (breast cell) ( 132 ) , muscle ( 6 , 38 , 153 ) , myoblast ( 97 ) , myocardium ( 36 , 138 ) , myocyte ( 168 ) , myocyte-heart ( 40 , 49 , 64 , 72 , 93 , 102 , 103 , 109 , 144 , 152 , 164 ) , neuron ( 96 ) , neuron-'brain, cerebellum' ( 180 , 234 ) , neuron-'brain, cerebral cortex' ( 131 ) , neuron-'brain, hippocampus' ( 5 , 41 , 170 , 214 ) , neutrophil-blood ( 63 ) , oligodendrocyte ( 227 , 236 ) , pancreatic acini ( 119 ) , PC-12 (chromaffin) ( 22 , 45 , 65 , 96 , 151 , 154 , 161 , 180 , 187 , 188 , 212 , 233 ) , penis ( 159 ) , platelet ( 31 ) , pulmonary artery ( 15 ) , RAEC (endothelial) ( 124 ) , Rat1 (fibroblast) ( 44 , 112 , 197 ) , Rat2 (fibroblast) ( 228 ) , RAW 264.7 (macrophage) ( 55 ) , RBL-2H3 (basophil) ( 230 ) , retina ( 195 , 237 ) , retinal ganglion ( 182 ) , RFPEC (endothelial) ( 178 ) , RIE (epithelial) ( 107 , 114 , 136 ) , RIE (epithelial) [PPAR-gamma (mouse)] ( 136 ) , RIN (epithelial) ( 181 ) , RM-4 (mesothelial) ( 189 ) , rMC-1 ( 108 ) , RPE-1 (retinal) ( 68 ) , RPE-J (epithelial) ( 68 ) , Schwann ( 85 ) , sertoli-testis ( 179 ) , SH-SY5Y (neural crest) ( 180 ) , SN4741 (neuron) ( 188 ) , spinal cord ( 50 ) , thoracic aorta ( 94 ) , Tibialis anterior ( 34 ) , vascular smooth muscle cell ('muscle, smooth') ( 126 , 145 , 209 , 222 , 225 ) , vein ( 218 )

Upstream Regulation
Regulatory protein:	ADCY6 (mouse) ( 102 ) , AKAP12 (rat) ( 85 ) , Akt1 (rat) ( 205 ) , AS160 (human) ( 6 ) , BCAT1 (mouse) ( 35 ) , CREB (human) ( 67 ) , DISC1 (human) ( 131 ) , DYN1 (rat) ( 73 ) , EEA1 (rat) ( 73 ) , FAK (rat) ( 103 , 132 , 143 ) , GJA1 (rat) ( 42 ) , GRK2 (rat) ( 40 ) , HMOX1 (rat) ( 72 ) , HSP27 (human) ( 16 ) , ILK (human) ( 107 ) , IRS1 (human) ( 67 ) , IRS1 (rat) ( 115 ) , IRS2 (human) ( 67 ) , ITGA5 (human) ( 114 ) , KRas (rat) ( 229 ) , LKB1 (human) ( 144 ) , Mer (rat) ( 235 ) , MKK4 (human) ( 152 ) , mTOR (rat) ( 124 ) , MYDGF (rat) ( 49 ) , OGT (human) ( 104 ) , PIK3C2A (human) ( 117 ) , PIK3CA (rat) ( 212 ) , PKCA (rat) ( 73 , 222 ) , PKCB (human) ( 222 ) , PKCD (mouse) ( 106 , 222 ) , PKCD (rat) ( 114 ) , RAC1 (rat) ( 122 ) , Raptor (rat) ( 124 ) , Ren2 (mouse) ( 94 ) , RICTOR (human) ( 124 ) , SERPINA3K (rat) ( 108 ) , SHC1 (rat) ( 211 ) , SHIP-2 (human) ( 211 ) , SHP-2 (rat) ( 103 ) , Src (rat) ( 55 ) , THY1 (rat) ( 9 ) , TIMP3 (human) ( 22 )
Putative in vivo kinases:	PKCA (rat) ( 178 ) , PKCE (mouse) ( 113 )
Kinases, in vitro:	PKCA (human) ( 178 )
Putative upstream phosphatases:	PHLPP (human) ( 26 ) , PPP2CA (rat) ( 224 )
Treatments:	1,25D ( 19 ) , 1400W ( 87 ) , 2-AP ( 195 ) , 2-deoxyglucose ( 206 ) , 3-chloroacetyl-indole ( 16 ) , 4-AP ( 41 ) , 4-HT ( 235 ) , 5-thio-glucose ( 206 ) , 6-OHDA ( 180 ) , 8-CPT-2Me-cAMP ( 11 ) , 8-OH-DPAT ( 158 ) , 8-Rp-cAMP ( 102 ) , A-443654 ( 66 ) , A304000 ( 101 ) , acadesine ( 130 , 155 , 217 ) , acetominophen ( 149 ) , action_potential ( 62 ) , ADP ( 31 ) , adrenalectomy ( 138 ) , adriamycin ( 132 ) , AEBSF ( 87 ) , AG1024 ( 89 , 126 ) , AG1296 ( 68 ) , AG1478 ( 68 , 140 , 167 , 188 , 229 ) , AG879 ( 198 ) , Akt-I-1,2 ( 62 ) , Akt_inhibitor_X ( 62 ) , AlCl3 ( 25 ) , alloxan ( 104 ) , amino_acid_starvation ( 80 ) , amino_acids ( 176 , 219 ) , androgen ( 34 ) , angiopoietin-1 ( 164 ) , angiopoietin-2 ( 40 , 164 ) , angiotensin ( 145 , 167 ) , angiotensin_2 ( 11 , 73 , 87 , 89 , 194 ) , anisomycin ( 195 ) , antibody ( 189 , 203 , 207 ) , API-2 ( 93 ) , APV ( 62 ) , aripiprazole ( 45 ) , artery ligation ( 169 ) , asbestos ( 189 ) , AZD5363 ( 22 ) , BADGP ( 104 ) , BBG ( 163 ) , BDNF ( 81 , 84 , 86 , 161 , 170 , 198 ) , berberine ( 56 , 79 ) , beta-amyloid_25-35 ( 65 ) , betacellulin ( 177 ) , bicuculline ( 41 ) , blood pressure ( 168 ) , bromocriptine ( 188 ) , bryostatin_1 ( 117 ) , buspirone ( 158 ) , C2-ceramide ( 122 , 224 ) , C5b-9 ( 227 ) , calyculin_A ( 117 , 201 ) , cAMP_analog ( 3 , 85 ) , cariporide ( 93 ) , CDDO-Me ( 16 ) , cell_adhesion ( 107 , 197 ) , cell_detachment ( 150 ) , ceramide ( 191 ) , cGMP_analog ( 156 ) , cholecystokinin ( 119 ) , cisplatin ( 23 , 129 ) , clopidogrel ( 31 ) , Clostridium_lethal_toxin ( 230 ) , Clostridium_toxin_B ( 230 ) , clozapine ( 45 ) , CNQX ( 62 ) , colforsin ( 127 , 195 , 216 , 223 , 228 , 234 ) , compound_401 ( 112 ) , compound_C ( 100 ) , copper ( 21 ) , CORM-2 ( 72 ) , CPA ( 102 ) , CT98014 ( 116 ) , culturing_of_cells ( 121 , 148 ) , curcumin ( 21 ) , cyclic_stretch ( 103 ) , D-allulose ( 20 ) , deferoxamine ( 21 ) , deoxygenation ( 43 ) , depolarization ( 223 ) , development ( 10 , 12 , 141 ) , dexamethasone ( 160 ) , DHC ( 224 ) , DHEA ( 3 ) , DiC8 ( 117 ) , DTG ( 96 ) , eflornithine ( 137 ) , EGF ( 65 , 99 , 129 , 140 , 154 , 188 , 221 , 228 ) , EGTA ( 163 ) , electrical_stimulation ( 18 ) , Electroacupuncture ( 29 ) , endothelin ( 89 , 95 ) , estradiol ( 118 ) , ethanol ( 146 , 158 , 171 ) , exenatide ( 74 ) , exercise ( 4 , 6 , 7 , 10 , 54 , 58 , 77 , 160 , 190 , 220 ) , fasting ( 82 , 153 ) , fibronectin ( 107 , 114 ) , fluid_shear_stress ( 159 ) , fluorouracil ( 23 ) , fMLP ( 63 ) , food deprivation ( 105 ) , fructose-rich diet ( 7 ) , furosemide ( 184 ) , G-1 ( 1 ) , GF109203X ( 191 , 222 ) , ghrelin ( 38 ) , GLP-2 ( 216 ) , glucagon ( 176 ) , glucosamine ( 104 , 181 ) , glucose ( 126 , 205 , 206 , 221 ) , glucose_oxidase ( 122 ) , glutamic acid ( 57 ) , Go_6976 ( 222 ) , Go_6983 ( 222 ) , GRGDSP ( 184 , 189 ) , Gynostemma_Extract ( 5 ) , H-89 ( 11 , 102 , 120 ) , H2O2 ( 33 , 108 , 188 ) , haloperidol ( 45 , 96 ) , heating ( 4 ) , hemorrhage ( 175 ) , heregulin ( 236 ) , HGF ( 119 ) , high-fat diet ( 1 , 20 ) , hirudin ( 68 ) , HM-chromanone ( 13 ) , Hydroxypropyl_Cellulose ( 20 ) , hypertension ( 185 , 218 ) , hypoxia ( 15 , 124 , 152 , 157 , 206 , 233 ) , hypoxia/reoxygenation ( 36 , 152 , 183 ) , IGF-1 ( 64 , 88 , 109 , 135 , 155 , 161 , 178 , 205 , 213 , 221 , 223 , 232 , 234 , 236 ) , IGF-2 ( 88 , 237 ) , insulin ( 3 , 6 , 35 , 38 , 44 , 61 , 66 , 70 , 77 , 80 , 82 , 87 , 92 , 97 , 101 , 106 , 116 , 118 , 122 , 125 , 130 , 138 , 139 , 143 , 153 , 160 , 166 , 173 , 175 , 176 , 181 , 182 , 184 , 186 , 191 , 196 , 201 , 211 , 215 , 216 , 219 , 220 , 222 , 224 , 232 , 235 ) , Intralipid ( 135 ) , ipsapirone ( 158 ) , IR-A48 ( 44 ) , irbesartan ( 139 ) , ischemia ( 78 ) , ischemia/reperfusion ( 30 , 36 , 71 , 78 , 133 , 148 , 152 , 174 , 231 ) , iso-PPADS ( 163 ) , isoproterenol ( 140 ) , kainic_acid ( 210 , 214 ) , KN-62 ( 68 ) , KN-92 ( 68 ) , L-NAME ( 236 ) , laminin-1 ( 164 ) , laser_treatment ( 65 ) , leptin ( 70 , 76 , 91 , 115 , 196 ) , leucine ( 110 ) , leucovorin ( 23 ) , liothyronine ( 100 , 172 ) , lithium ( 101 , 223 ) , liver ischemic postconditioning ( 17 ) , Longdan Xiegan Tang ( 28 ) , loquat leaf extract ( 18 ) , LS-102 ( 36 ) , LY294002 ( 31 , 50 , 56 , 57 , 67 , 68 , 75 , 81 , 86 , 96 , 107 , 112 , 115 , 117 , 119 , 129 , 145 , 148 , 150 , 151 , 154 , 157 , 165 , 172 , 178 , 182 , 188 , 193 , 194 , 195 , 201 , 204 , 206 , 209 , 216 , 220 , 222 , 225 , 229 , 232 , 237 ) , lysophosphatidylcholine ( 222 ) , maduramicin ( 24 ) , MCAO/R ( 27 ) , MCTP ( 32 ) , meal feeding ( 134 , 147 ) , mechanical stress ( 141 , 163 , 165 ) , metamfetamine ( 48 ) , metformin ( 26 ) , metoprolol ( 138 ) , MK-2206 ( 33 , 61 ) , morin ( 26 ) , MPP+ ( 90 ) , MRS_2179 ( 163 ) , muscle atrophy ( 192 ) , muscle contraction ( 82 ) , myricetin ( 69 , 87 ) , N-ethylmaleimede ( 209 ) , NAC ( 8 , 33 , 209 ) , Naringenin ( 31 ) , neuregulin ( 193 ) , neurotrophin-3 ( 161 , 170 ) , neurotrophin-4 ( 161 ) , NGF ( 151 , 154 , 161 , 170 , 187 , 212 , 233 ) , NH4Cl ( 93 ) , NKH_477 ( 67 ) , NSC23766 ( 47 ) , obesity-inducing diet ( 77 ) , OGD/R ( 22 ) , okadaic_acid ( 83 , 117 , 209 , 224 ) , olanzapine ( 28 ) , oleic_acid ( 205 ) , osmotic_stress ( 201 ) , osmotin ( 57 ) , OXO ( 114 ) , p18_peptide ( 107 ) , painful stimulus ( 29 ) , palmitate ( 13 , 38 ) , PCP ( 86 ) , PD169316 ( 186 ) , PD98059 ( 86 , 90 , 148 , 151 , 154 , 186 , 198 , 222 , 229 , 236 ) , PDGF ( 112 , 162 , 209 , 225 , 232 ) , Peganum harmala ( 25 ) , phenylephrine ( 40 , 64 ) , phorbol_ester ( 106 , 117 , 222 ) , piclidenoson ( 142 ) , PIK90 ( 92 ) , pioglitazone ( 27 ) , PKI ( 102 ) , PKI-(14-22)amide ( 123 ) , pleiotrophin ( 109 ) , PP1 ( 172 ) , PP2 ( 74 , 89 , 103 , 107 , 137 , 172 , 184 , 188 ) , PP242 ( 92 ) , PP3 ( 89 ) , PP30 ( 92 ) , PPACK ( 68 ) , pramipexole ( 188 ) , PRL ( 226 ) , PTX ( 188 ) , PUGNAc ( 104 ) , rapalink1 ( 30 ) , rapamycin ( 32 , 80 , 81 , 92 , 112 , 117 , 124 , 162 , 236 ) , reelin ( 204 ) , refeeding ( 82 ) , renal ischemia/reperfusion injury ( 17 ) , resistin ( 71 ) , resveratrol ( 202 ) , RGDS ( 137 , 189 ) , Ro-32-0432 ( 68 ) , Ro31-8220 ( 191 , 198 ) , ROCK inhibitor II ( 93 ) , rosiglitazone ( 215 ) , rosuvastatin ( 19 ) , rottlerin ( 222 ) , RS5444 ( 136 ) , salicylate ( 186 ) , SB202190 ( 148 ) , SB203580 ( 148 , 236 ) , seliciclib ( 193 ) , sepsis ( 110 , 207 ) , serum ( 202 , 216 ) , sildenafil ( 168 ) , siRNA ( 26 , 143 ) , SMI11293 ( 84 ) , SN-50 ( 213 ) , SP600125 ( 152 ) , spironolactone ( 94 ) , staurosporine ( 5 ) , Strictosamide ( 2 ) , sulforaphane ( 39 ) , tamoxifen ( 75 ) , tauroursodeoxycholic_acid ( 200 ) , tautomycin ( 117 ) , TCH-116 ( 63 ) , testosterone ( 97 ) , TeTx ( 90 , 198 ) , TGF-alpha ( 221 ) , TGF-beta ( 111 , 123 ) , thrombin ( 68 , 140 , 225 ) , TMCB ( 8 ) , TNF ( 9 , 98 , 137 , 186 , 224 ) , TNP-OVA ( 230 ) , TPCK ( 213 ) , trauma ( 175 ) , tri-nitrobenzene_sulfonic_acid ( 50 ) , trifluoperazine ( 68 ) , triterpenoid saponins from Ilex cornuta ( 33 ) , TSH ( 120 ) , U0126 ( 81 , 87 , 107 ) , U73122 ( 68 ) , UCN-01 ( 66 , 173 ) , urofollitropin ( 123 ) , V-100 ( 152 ) , V-150 ( 152 ) , vanadate ( 133 , 148 , 201 , 236 ) , VEGF ( 148 ) , vitronectin ( 164 ) , VX702 ( 152 ) , whey protein diet ( 58 ) , wortmannin ( 11 , 66 , 68 , 80 , 90 , 95 , 100 , 115 , 119 , 123 , 127 , 132 , 150 , 154 , 163 , 165 , 170 , 172 , 179 , 188 , 194 , 198 , 201 , 204 , 220 , 222 , 230 , 232 , 233 , 234 , 236 ) , Y27632 ( 107 ) , Yoda1 ( 15 )

Downstream Regulation
Effects of modification on Akt1:	activity, induced ( 163 , 168 , 189 ) , enzymatic activity, induced ( 54 , 93 , 125 , 126 , 225 , 235 ) , intracellular localization ( 102 , 226 ) , molecular association, regulation ( 225 ) , phosphorylation ( 26 , 68 , 93 ) , protein conformation ( 66 )
Effects of modification on biological processes:	apoptosis, altered ( 33 ) , apoptosis, inhibited ( 21 , 22 , 26 , 27 , 57 , 75 , 236 ) , autophagy, induced ( 8 , 16 ) , cell adhesion, induced ( 31 ) , cell cycle regulation ( 24 ) , cell differentiation, altered ( 85 ) , cell growth, induced ( 24 , 68 ) , signaling pathway regulation ( 3 , 24 , 26 , 57 , 64 , 67 , 68 , 69 , 91 , 93 )
Induce interaction with:	RAF1 (rat) ( 225 )

Disease / Diagnostics Relevance
Relevant diseases:	type 2 diabetes ( 19 , 26 , 54 ) , major depressive disorder ( 131 ) , NAFLD ( 54 ) , OA ( 56 ) , Status epilepticus ( 16 )

References
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