Thr320
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Home > Phosphorylation Site Page: > Thr320  -  PPP1CA (rat)

Site Information
NPGGRPItPPRNSAK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448686

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 3 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 , 2 , 4 ) , western blotting ( 1 , 2 , 4 )
Disease tissue studied:
adrenal cancer ( 4 ) , pheochromocytoma ( 4 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 1 ) , 293 (epithelial) ( 1 ) , neuron-'brain, hippocampus' ( 2 ) , PC-12 (chromaffin) ( 4 )

Upstream Regulation
Regulatory protein:
CDK5R1 (rat) ( 1 ) , PPP1R1A (rat) ( 1 ) , PPP1R2 (rat) ( 1 )
Putative in vivo kinases:
CDK5 (rat) ( 1 )
Kinases, in vitro:
CDK1 (human) ( 3 )
Treatments:
APV_withdrawal ( 2 ) , ciclosporin ( 1 ) , CNQX ( 1 ) , desmopressin ( 1 ) , FK506 ( 1 ) , fostriecin ( 1 ) , NGF ( 4 ) , NMDA ( 1 ) , olomoucine ( 4 ) , seliciclib ( 1 )

Downstream Regulation
Effects of modification on PPP1CA:
enzymatic activity, inhibited ( 1 )

References 

1

Hou H, et al. (2013) Synaptic NMDA receptor stimulation activates PP1 by inhibiting its phosphorylation by Cdk5. J Cell Biol 203, 521-35
24189275   Curated Info

2

Chung HJ, et al. (2009) Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels. Proc Natl Acad Sci U S A 106, 629-34
19118198   Curated Info

3

Blethrow JD, Glavy JS, Morgan DO, Shokat KM (2008) Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A 105, 1442-7
18234856   Curated Info

4

Li T, Chalifour LE, Paudel HK (2007) Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. J Biol Chem 282, 6619-28
17202132   Curated Info

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