Thr123
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Home > Phosphorylation Site Page: > Thr123  -  P38A (human)

Site Information
IVkCQkLtDDHVQFL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471074

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , 3T3-L1 (fibroblast) ( 1 ) , macrophage-blood ( 1 ) , monocyte ( 1 ) , splenocyte ( 1 )

Upstream Regulation
Putative in vivo kinases:
GRK2 (human) ( 1 )
Kinases, in vitro:
GRK2 (human) ( 1 )
Treatments:
differentiation ( 1 )

Downstream Regulation
Effects of modification on P38A:
enzymatic activity, inhibited ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
cell differentiation, altered ( 1 )
Inhibit interaction with:
MAPKAPK2 (human) ( 1 ) , MKK6 (human) ( 1 )

References 

1

Peregrin S, et al. (2006) Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK. Curr Biol 16, 2042-7
17055984   Curated Info

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