Thr560
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Home > Phosphorylation Site Page: > Thr560  -  PKCZ (mouse)

Site Information
TSEPVQLtPDDEDVI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447572

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mass spectrometry ( 3 ) , mutation of modification site ( 4 ) , phospho-antibody ( 1 , 4 ) , western blotting ( 4 )
Relevant cell line - cell type - tissue:
chondrocyte ( 4 ) , endothelial-retina ( 1 ) , kidney ( 3 )

Upstream Regulation
Putative in vivo kinases:
PKCZ (mouse) ( 1 )
Kinases, in vitro:
PKCZ (human) ( 4 )
Treatments:
VEGF ( 1 )

Downstream Regulation
Effects of modification on PKCZ:
activity, induced ( 1 ) , enzymatic activity, induced ( 4 )

References 

1

Nakayama M, et al. (2013) Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol 15, 249-60
23354168   Curated Info

2

Mayanglambam A, Bhavanasi D, Vijayan KV, Kunapuli SP (2011) Differential dephosphorylation of the protein kinase C-zeta (PKCζ) in an integrin αIIbβ3-dependent manner in platelets. Biochem Pharmacol 82, 505-13
21645497   Curated Info

3

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

4

Kim JS, et al. (2005) p38 kinase mediates nitric oxide-induced apoptosis of chondrocytes through the inhibition of protein kinase C zeta by blocking autophosphorylation. Cell Death Differ 12, 201-12
15665819   Curated Info

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