Lys315
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Home > Ubiquitylation Site Page: > Lys315  -  IRF3 (human)

Site Information
DGEVPkDkEGGVFDL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 56403900

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
fibrosarcoma of soft tissue ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
DHX58 (human) ( 1 )
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on IRF3:
intracellular localization ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 )

References 

1

Chattopadhyay S, et al. (2016) Ubiquitination of the Transcription Factor IRF-3 Activates RIPA, the Apoptotic Pathway that Protects Mice from Viral Pathogenesis. Immunity 44, 1151-61
27178468   Curated Info