Lys302
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Home > Acetylation Site Page: > Lys302  -  C/EBP-alpha (human)

Site Information
AVRkSRDkAKQRNVE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 56394105

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 1 ) , acute myelogenous leukemia ( 1 ) , chronic myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
G-CSF ( 1 )

Downstream Regulation
Effects of modification on C/EBP-alpha:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell differentiation, inhibited ( 1 ) , transcription, inhibited ( 1 )
Inhibit interaction with:
DNA ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
acute myelogenous leukemia ( 1 )

References 

1

Bararia D, et al. (2016) Acetylation of C/EBPα inhibits its granulopoietic function. Nat Commun 7, 10968
27005833   Curated Info