Ser25

Site Information
SVDSRSCsIPLVAPR SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 448659

In vivo Characterization
Methods used to characterize site in vivo:	2D analysis ( 2 ) , [32P] bio-synthetic labeling ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phosphopeptide mapping ( 1 , 2 )
Relevant cell line - cell type - tissue:	3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 2 ) , 3T3 (fibroblast) ( 1 ) , COS (fibroblast) ( 1 , 2 )

Downstream Regulation
Effects of modification on MOS:	enzymatic activity, inhibited ( 1 )

References
1	Yang Y, et al. (1998) Evidence of a functional interaction between serine 3 and serine 25 Mos phosphorylation sites. A dominant inhibitory role of serine 25 phosphorylation on Mos protein kinase. J Biol Chem 273, 15946-53 9632642 Curated Info
2	Yang Y, Herrmann CH, Arlinghaus RB, Singh B (1996) Inhibition of v-Mos kinase activity by protein kinase A. Mol Cell Biol 16, 800-9 8622681 Curated Info