Ser363
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Home > Phosphorylation Site Page: > Ser363  -  MOR-1 (mouse)

Site Information
STIEQQNsARIRQNt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447783

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 6 , 9 , 10 ) , mass spectrometry (in vitro) ( 8 ) , mutation of modification site ( 1 , 3 , 7 , 8 ) , phospho-antibody ( 4 , 7 , 8 ) , western blotting ( 4 , 7 , 8 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 4 , 7 ) , brain ( 2 , 6 , 9 , 10 ) , brain [MOR-1 (mouse), homozygous knockout] ( 4 ) , CHO (fibroblast) ( 8 ) , neuron-brain ( 3 )

Upstream Regulation
Regulatory protein:
MOR-1 (mouse) ( 4 )
Putative in vivo kinases:
PKCA (human) ( 4 , 8 )
Kinases, in vitro:
PKCA (human) ( 8 ) , PKCB iso2 (human) ( 8 ) , PKCE (human) ( 8 ) , PKCG (human) ( 8 )
Treatments:
DAMGO ( 4 , 7 ) , etonitazene ( 2 , 4 ) , fentanyl ( 2 ) , morphine ( 2 , 4 ) , phorbol_ester ( 4 , 8 ) , Ro-32-0432 ( 4 )

Downstream Regulation
Effects of modification on MOR-1:
receptor recycling, induced ( 1 , 3 )

References 

1

Kunselman JM, Zajac AS, Weinberg ZY, Puthenveedu MA (2019) Homologous Regulation of Mu Opioid Receptor Recycling by G , Protein Kinase C, and Receptor Phosphorylation. Mol Pharmacol 96, 702-710
31575621   Curated Info

2

Moulédous L, et al. (2015) Phosphoproteomic analysis of the mouse brain mu-opioid (MOP) receptor. FEBS Lett 589, 2401-8
26226422   Curated Info

3

Bowman SL, et al. (2015) Cell-autonomous regulation of Mu-opioid receptor recycling by substance P. Cell Rep 10, 1925-36
25801029   Curated Info

4

Illing S, Mann A, Schulz S (2014) Heterologous regulation of agonist-independent μ-opioid receptor phosphorylation by protein kinase C. Br J Pharmacol 171, 1330-40
24308893   Curated Info

5

Just S, et al. (2013) Differentiation of opioid drug effects by hierarchical multi-site phosphorylation. Mol Pharmacol 83, 633-9
23239825   Curated Info

6

Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9
22807455   Curated Info

7

Doll C, et al. (2011) Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies. Br J Pharmacol 164, 298-307
21449911   Curated Info

8

Feng B, Li Z, Wang JB (2011) Protein kinase C-mediated phosphorylation of the μ-opioid receptor and its effects on receptor signaling. Mol Pharmacol 79, 768-75
21212139   Curated Info

9

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

10

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info