Thr555
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Home > Phosphorylation Site Page: > Thr555  -  CRMP-2 (mouse)

Site Information
DNIPRRttQRIVAPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448084

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , mass spectrometry ( 6 ) , mutation of modification site ( 2 , 3 , 4 , 5 ) , phospho-antibody ( 2 , 3 , 5 ) , western blotting ( 2 , 3 , 5 )
Relevant cell line - cell type - tissue:
'brain, cerebellum' ( 2 ) , 'neuron, cortical' ( 4 ) , 'neuron, cortical'-brain ( 5 ) , 'neuron, Purkinje'-'brain, cerebellum' ( 2 ) , COS (fibroblast) ( 3 ) , fibroblast-lung ( 6 ) , HeLa (cervical) ( 2 ) , neuron-dorsal root ganglia ( 3 ) , neuron:synaptosome-'brain, cerebral cortex' ( 5 )

Upstream Regulation
Putative in vivo kinases:
CAMK2A (human) ( 5 ) , PKACA (mouse) ( 3 ) , PKCG (mouse) ( 2 )
Kinases, in vitro:
CAMK2A (human) ( 5 )
Treatments:
autocamtide_inhibitory_peptide ( 5 ) , bisindolylmaleimide ( 3 ) , calpeptin ( 5 ) , glutamic acid ( 5 ) , GSK429286A ( 3 ) , ischemia/reperfusion ( 5 ) , kainic_acid ( 3 ) , KN-93 ( 5 ) , LY294002 ( 5 ) , PD98059 ( 5 ) , phorbol_ester ( 2 ) , Y27632 ( 5 )

Downstream Regulation
Effects of modification on CRMP-2:
protein processing ( 5 )
Effects of modification on biological processes:
cell growth, altered ( 4 ) , cell growth, inhibited ( 2 ) , cytoskeletal reorganization ( 2 , 5 )

References 

1

Zheng K, et al. (2021) miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease. Nat Commun 12, 1903
33771994   Curated Info

2

Winkler SC, Shimobayashi E, Kapfhammer JP (2020) PKCĪ³-Mediated Phosphorylation of CRMP2 Regulates Dendritic Outgrowth in Cerebellar Purkinje Cells. Mol Neurobiol
32860158   Curated Info

3

Marques JM, et al. (2013) CRMP2 Tethers Kainate Receptor Activity to Cytoskeleton Dynamics during Neuronal Maturation. J Neurosci 33, 18298-310
24227739   Curated Info

4

Shinkai-Ouchi F, et al. (2010) Identification and structural analysis of C-terminally truncated collapsin response mediator protein-2 in a murine model of prion diseases. Proteome Sci 8, 53
20961402   Curated Info

5

Hou ST, et al. (2009) CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity. J Neurochem 111, 870-81
19735446   Curated Info

6

Guo A (2009) CST Curation Set: 6842; Year: 2009; Biosample/Treatment: cell line, mouse lung fibroblasts/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS*/T*) (23C8D2) Rabbit mAb Cat#: 10001, PTMScan(R) Phospho-Akt Substrate Motif (RXRXXS*/T*) Immunoaffinity Beads Cat#: 1979
Curated Info