Ser9
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Home > Phosphorylation Site Page: > Ser9  -  SYN1 (mouse)

Site Information
NYLRRRLsDSNFMAN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448378

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 11 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 7 , 8 , 11 , 12 ) , microscopy-colocalization with upstream kinase ( 14 ) , mutation of modification site ( 2 , 4 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 6 , 9 , 10 , 13 , 14 ) , western blotting ( 1 , 2 , 3 , 4 , 6 , 9 , 10 , 11 , 13 , 14 )
Relevant cell line - cell type - tissue:
'brain, amygdala' ( 6 ) , 'brain, cerebral cortex' ( 3 ) , 'brain, hippocampus' ( 6 , 9 , 11 ) , 'brain, striatum' ( 4 , 6 , 10 , 13 ) , 'neuron, hippocampal, CA1 pyramidal' ( 2 ) , brain ( 7 , 8 , 12 ) , epithelial-lens ( 14 ) , HEK293T (epithelial) ( 2 ) , neuron-'brain, cerebral cortex' ( 1 ) , neuron-'brain, hippocampus' ( 3 )

Upstream Regulation
Regulatory protein:
ARPP-21 (mouse) ( 6 )
Treatments:
9d ( 9 ) , CGS_21680 ( 13 ) , clozapine ( 3 ) , colforsin ( 13 ) , deoxygenation ( 1 ) , ischemia/reperfusion ( 1 ) , papaverine ( 10 ) , rolipram ( 10 ) , seliciclib ( 4 )

Downstream Regulation
Effects of modification on SYN1:
molecular association, regulation ( 2 )
Inhibit interaction with:
ACTB (mouse) ( 2 )

References 

1

Zhang N, et al. (2018) cPKCγ alleviates ischemic injury through modulating synapsin Ia/b phosphorylation in neurons of mice. Brain Res Bull 142, 156-162
30016727   Curated Info

2

Park D, et al. (2017) Activation of CaMKIV by soluble amyloid-β1-42 impedes trafficking of axonal vesicles and impairs activity-dependent synaptogenesis. Sci Signal 10
28698220   Curated Info

3

Choi Y, et al. (2017) Clozapine Improves Memory Impairment and Reduces Aβ Level in the Tg-APPswe/PS1dE9 Mouse Model of Alzheimer's Disease. Mol Neurobiol 54, 450-460
26742522   Curated Info

4

Plattner F, et al. (2015) The role of ventral striatal cAMP signaling in stress-induced behaviors. Nat Neurosci 18, 1094-100
26192746   Curated Info

5

Qin Z, et al. (2013) Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent. PLoS One 8, e80758
24224061   Curated Info

6

Davis MM, et al. (2012) Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficits. Eur J Neurosci 35, 300-8
22250817   Curated Info

7

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

8

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

9

Tallent MK, et al. (2009) In vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation. J Biol Chem 284, 174-81
19004831   Curated Info

10

Nishi A, et al. (2008) Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum. J Neurosci 28, 10460-71
18923023   Curated Info

11

John JP, Chen WQ, Pollak A, Lubec G (2007) Mass spectrometric studies on mouse hippocampal synapsins Ia, IIa, and IIb and identification of a novel phosphorylation site at serine-546. J Proteome Res 6, 2695-710
17579389   Curated Info

12

Guo A (2007) CST Curation Set: 2718; Year: 2007; Biosample/Treatment: tissue, brain/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST](D/E)X(D/E)
Curated Info

13

Sahin B, et al. (2007) Evaluation of neuronal phosphoproteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signaling. Brain Res 1129, 1-14
17157277   Curated Info

14

Frederikse PH, et al. (2004) Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation. Mol Vis 10, 794-804
15529118   Curated Info