Ser338
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Home > Phosphorylation Site Page: > Ser338  -  RAF1 (rat)

Site Information
RPRGQRDsSyyWEIE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447742

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'brain, striatum' ( 1 ) , mesangial ( 2 ) , myocyte ( 4 ) , PC-12 (chromaffin) ( 3 )

Upstream Regulation
Treatments:
cytochalasin_D ( 2 ) , GW_5074 ( 2 ) , LY294002 ( 2 ) , mechanical stress ( 2 ) , NGF ( 3 ) , okadaic_acid ( 1 ) , wortmannin ( 2 ) , Y27632 ( 2 )

References 

1

Mao L, et al. (2005) Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons. J Biol Chem 280, 12602-10
15661743   Curated Info

2

Krepinsky JC, et al. (2005) Stretch-induced Raf-1 activation in mesangial cells requires actin cytoskeletal integrity. Cell Signal 17, 311-20
15567062   Curated Info

3

Hekman M, et al. (2004) Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites. J Biol Chem 279, 14074-86
14688280   Curated Info

4

Clerk A, et al. (2001) Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1. Mol Cell Biol 21, 1173-84
11158304   Curated Info