Lys7

Site Information
_MASLTVkAyLLGkE SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 55588403

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 , 2 , 3 ) , microscopy-colocalization with upstream kinase ( 2 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:	leukemia ( 2 ) , acute myelogenous leukemia ( 2 ) , lung cancer ( 2 ) , non-small cell lung cancer ( 2 ) , non-small cell lung adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:	A549 (pulmonary) ( 2 ) , HEK293T (epithelial) ( 1 , 2 , 3 ) , MEF (fibroblast) ( 3 ) , THP1 (myeloid) ( 2 )

Downstream Regulation
Effects of modification on SQSTM1:	activity, induced ( 2 ) , molecular association, regulation ( 1 , 3 ) , protein degradation ( 1 , 2 )
Effects of modification on biological processes:	autophagy, induced ( 1 , 2 )
Induce interaction with:	KEAP1 (human) ( 1 ) , SQSTM1 (human) ( 1 )
Inhibit interaction with:	SQSTM1 (human) ( 3 )

References
1	Lee B, et al. (2023) USP13 deubiquitinates p62/SQSTM1 to induce autophagy and Nrf2 release for activating antioxidant response genes. Free Radic Biol Med 208, 820-832 37776917 Curated Info
2	Xie W, et al. (2022) OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity. Autophagy 18, 2288-2302 35100065 Curated Info
3	Pan JA, et al. (2016) TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis. Mol Cell 61, 720-33 26942676 Curated Info