Tyr881
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Home > Phosphorylation Site Page: > Tyr881  -  Pyk2 (rat)

Site Information
DRTDDLVyHNVMTLV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447958

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 4 ) , myocyte-heart ( 2 ) , pancreas ( 3 ) , small mesenteric arteries ( 1 )

Upstream Regulation
Treatments:
CCK-JMV ( 3 ) , cholecystokinin ( 3 ) , cytochalasin_D ( 1 ) , electrical_stimulation ( 4 ) , endothelin ( 1 ) , GF109203X ( 3 ) , norepinephrine ( 1 ) , thapsigargin ( 3 )

References 

1

Ohanian V, Gatfield K, Ohanian J (2005) Role of the actin cytoskeleton in G-protein-coupled receptor activation of PYK2 and paxillin in vascular smooth muscle. Hypertension 46, 93-9
15911746   Curated Info

2

Melendez J, et al. (2004) Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. J Biol Chem 279, 53516-23
15322113   Curated Info

3

Pace A, et al. (2003) Phosphospecific site tyrosine phosphorylation of p125FAK and proline-rich kinase 2 is differentially regulated by cholecystokinin receptor type A activation in pancreatic acini. J Biol Chem 278, 19008-16
12651850   Curated Info

4

Jeon SH, et al. (2001) Electroconvulsive shock increases the phosphorylation of Pyk2 in the rat hippocampus. Biochem Biophys Res Commun 282, 1026-30
11352655   Curated Info