Thr75
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Home > Phosphorylation Site Page: > Thr75  -  IRF3 (human)

Site Information
RDkPDLPtWkRNFRS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 55458201

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
MST1 (human) ( 1 )
Kinases, in vitro:
MST1 (human) ( 1 )

Downstream Regulation
Effects of modification on IRF3:
molecular association, regulation ( 1 ) , protein conformation ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )
Inhibit interaction with:
DNA ( 1 )

References 

1

Meng F, et al. (2016) Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation. Genes Dev 30, 1086-100
27125670   Curated Info