Ser110
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Home > Phosphorylation Site Page: > Ser110  -  LEO1 (human)

Site Information
DVDQHSGsEAPNDDE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 55377670

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 1 ) , acute myelogenous leukemia ( 1 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 1 ) , lung cancer ( 2 ) , non-small cell lung adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 1 ) , HEK293T (epithelial) ( 1 ) , HEL (erythroid) ( 1 ) , Molm 14 (myeloid) ( 1 ) , OCI/AML2 (myeloid) ( 1 ) , PC9 (pulmonary) ( 2 ) , TF-1 (erythroid) ( 1 )

Upstream Regulation
Putative upstream phosphatases:
PTP4A3 (human) ( 1 )
Phosphatases, in vitro:
PTP4A3 (human) ( 1 )
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on LEO1:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , carcinogenesis, inhibited ( 1 ) , cell growth, inhibited ( 1 ) , signaling pathway regulation ( 1 ) , transcription, inhibited ( 1 )
Inhibit interaction with:
CTNNB1 (human) ( 1 )

References 

1

Chong PSY, et al. (2018) Non-canonical activation of β-catenin by PRL-3 phosphatase in acute myeloid leukemia. Oncogene
30305722   Curated Info

2

Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448   Curated Info

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