Ser511
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Home > Phosphorylation Site Page: > Ser511  -  HSP75 (human)

Site Information
NrHLAEHsPyyEAMk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 55374803

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
brain cancer ( 1 ) , glioblastoma ( 1 ) , glioma ( 1 ) , lung cancer ( 2 ) , non-small cell lung adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:
MEF (fibroblast) ( 1 ) , PC9-IR (pulmonary) ( 2 ) , U87MG (glial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 1 ) , ERK2 (human) ( 1 )

Downstream Regulation
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 )

References 

1

Masgras I, et al. (2017) Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1. Cell Rep 18, 659-672
28099845   Curated Info

2

Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448   Curated Info