Ser70
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Home > Phosphorylation Site Page: > Ser70  -  Bcl-2 (rat)

Site Information
RDTAARTsPLRPLVA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448395

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , electrophoretic mobility shift ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 2 ) , IEC-6 (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (rat) ( 2 ) , MEK1 (rat) ( 1 ) , P38A (rat) ( 2 )
Putative upstream phosphatases:
PPP2CA (rat) ( 1 )
Treatments:
eflornithine ( 1 ) , okadaic_acid ( 1 ) , putrescine ( 1 ) , SB202190 ( 2 ) , SNP ( 2 ) , TNF ( 1 ) , U0126 ( 1 , 2 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, altered ( 1 , 2 )

References 

1

Ray RM, Bhattacharya S, Johnson LR (2005) Protein phosphatase 2A regulates apoptosis in intestinal epithelial cells. J Biol Chem 280, 31091-100
15994315   Curated Info

2

Ishikawa Y, et al. (2003) Regulation of Bax translocation through phosphorylation at Ser-70 of Bcl-2 by MAP kinase in NO-induced neuronal apoptosis. Mol Cell Neurosci 24, 451-9
14572466   Curated Info