Ser988
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Home > Phosphorylation Site Page: > Ser988  -  BRCA1 (human)

Site Information
PPLFPIksFVKTKCK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448526

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , microscopy-colocalization with upstream kinase ( 5 ) , mutation of modification site ( 1 , 3 , 5 ) , phospho-antibody ( 1 , 2 , 4 , 5 ) , western blotting ( 1 , 2 )
Disease tissue studied:
breast cancer ( 4 ) , breast adenocarcinoma ( 4 ) , breast ductal carcinoma ( 4 ) , colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Chk2 (human) ( 3 , 5 )
Kinases, in vitro:
Chk2 (human) ( 5 )
Putative upstream phosphatases:
PPP6C (human) ( 1 )
Treatments:
ionizing_radiation ( 2 , 4 , 5 ) , UV ( 4 )

Downstream Regulation
Effects of modification on BRCA1:
activity, induced ( 3 ) , intracellular localization ( 2 , 4 , 5 )

References 

1

Ertych N, et al. (2016) CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly. Proc Natl Acad Sci U S A 113, 1817-22
26831064   Curated Info

2

Takahashi A, et al. (2008) DNA damage recognition proteins localize along heavy ion induced tracks in the cell nucleus. J Radiat Res (Tokyo) 49, 645-52
18987440   Curated Info

3

Zhang J, et al. (2004) Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol Cell Biol 24, 708-18
14701743   Curated Info

4

Okada S, Ouchi T (2003) Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization. J Biol Chem 278, 2015-20
12427729   Curated Info

5

Lee JS, et al. (2000) hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404, 201-4
10724175   Curated Info