Tyr272
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Home > Phosphorylation Site Page: > Tyr272  -  PBK (human)

Site Information
DFDDEAYyAALGTRP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 54400800

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , immunoprecipitation ( 2 ) , microscopy-colocalization with upstream kinase ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 ) , gastric cancer ( 1 ) , gastric carcinoma ( 1 ) , lymphoma ( 2 ) , anaplastic large cell lymphoma ( 2 )
Relevant cell line - cell type - tissue:
HCT116 (intestinal) ( 2 ) , HCT15 (intestinal) ( 2 ) , HEK293T (epithelial) ( 1 , 2 ) , JB-6 (lymphocyte) ( 2 ) , MGC803 (gastric) ( 1 ) , SGC7901 (gastric) ( 1 ) , stomach ( 1 ) , SW480 (intestinal) ( 2 )

Upstream Regulation
Putative in vivo kinases:
Fyn (human) ( 1 )
Kinases, in vitro:
Fyn (human) ( 1 ) , Src (human) ( 2 )
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on PBK:
enzymatic activity, induced ( 2 ) , protein stabilization ( 2 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 , 2 ) , cell growth, induced ( 1 ) , cell motility, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
gastric cancer ( 1 )

References 

1

Peng S, et al. (2023) FYN/TOPK/HSPB1 axis facilitates the proliferation and metastasis of gastric cancer. J Exp Clin Cancer Res 42, 80
37016377   Curated Info

2

Xiao J, et al. (2016) Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon. Oncotarget 7, 24483-94
27016416   Curated Info

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