Tyr272
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Home > Phosphorylation Site Page: > Tyr272  -  PBK (human)

Site Information
DFDDEAYyAALGTRP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 54400800

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , microscopy-colocalization with upstream kinase ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , lymphoma ( 1 ) , anaplastic large cell lymphoma ( 1 )
Relevant cell line - cell type - tissue:
293T (epithelial) ( 1 ) , HCT116 (intestinal) ( 1 ) , HCT15 (intestinal) ( 1 ) , JB-6 (lymphocyte) ( 1 ) , SW480 (intestinal) ( 1 )

Upstream Regulation
Kinases, in vitro:
Src (human) ( 1 )

Downstream Regulation
Effects of modification on PBK:
enzymatic activity, induced ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 )

References 

1

Xiao J, et al. (2016) Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon. Oncotarget 7, 24483-94
27016416   Curated Info