Thr338
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Home > Phosphorylation Site Page: > Thr338  -  PDHK1 (human)

Site Information
LFNYMyStAPRPRVE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 54390604

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 ) , immunoprecipitation ( 4 ) , mass spectrometry ( 4 ) , mutation of modification site ( 4 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , phosphoamino acid analysis ( 4 ) , western blotting ( 1 , 2 , 3 , 4 )
Disease tissue studied:
brain cancer ( 1 , 2 , 4 ) , glioblastoma ( 1 , 2 , 4 ) , glioma ( 1 , 2 , 4 ) , cancer, squamous cell carcinoma ( 3 )
Relevant cell line - cell type - tissue:
breast ( 3 ) , esophagus ( 3 ) , liver ( 3 ) , lung ( 3 ) , stomach ( 3 ) , U-251 MG (glial) ( 2 ) , U87MG (glial) ( 1 , 2 , 4 )

Upstream Regulation
Putative in vivo kinases:
PGK1 (human) ( 1 , 4 )
Treatments:
CoCL2 ( 1 ) , EGF ( 1 ) , GQQ-792 ( 1 ) , hypoxia ( 2 ) , NG52 ( 2 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on PDHK1:
enzymatic activity, induced ( 4 )
Effects of modification on biological processes:
carcinogenesis, induced ( 3 , 4 ) , cell growth, induced ( 4 )

Disease / Diagnostics Relevance
Relevant diseases:
breast cancer ( 3 ) , esophageal carcinoma ( 3 ) , gastric cancer ( 3 ) , hepatocellular carcinoma ( 3 ) , lung cancer ( 3 )

References 

1

Wang Y, et al. (2020) Identification of a novel non-ATP-competitive protein kinase inhibitor of PGK1 from marine nature products. Biochem Pharmacol 183, 114343
33212041   Curated Info

2

Wang WL, et al. (2020) Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52. Acta Pharmacol Sin
32737469   Curated Info

3

Shao F, et al. (2019) Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis: a TCGA pan-cancer analysis. Cancer Commun (Lond) 39, 54
31578148   Curated Info

4

Li X, et al. (2016) Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. Mol Cell 61, 705-19
26942675   Curated Info