Tyr679
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Home > Phosphorylation Site Page: > Tyr679  -  PECAM-1 (mouse)

Site Information
PQNMDVEyTEVEVSS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448759

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
CSK (mouse) ( 2 ) , Fer (human) ( 1 ) , Lck (mouse) ( 2 )
Kinases, in vitro:
Fer (mouse) ( 1 )

Downstream Regulation
Effects of modification on PECAM-1:
molecular association, regulation ( 2 )
Induce interaction with:
SHP-1 (mouse) ( 2 ) , SHP-2 (mouse) ( 2 )

References 

1

Udell CM, et al. (2006) Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation. J Biol Chem 281, 20949-57
16731527   Curated Info

2

Cao MY, et al. (1998) Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases. J Biol Chem 273, 15765-72
9624175   Curated Info

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