Tyr454

Site Information
PRGAPAVysEkVMHM SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 54175479

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 )
Disease tissue studied:	brain cancer ( 1 ) , glioblastoma ( 1 ) , glioma ( 1 )
Relevant cell line - cell type - tissue:	LN428_LNZ308 (glial) [EGFR (human), transfection, EGFR (wildtype)] ( 1 ) , LN428_LNZ308 (glial) [EGFR (human), transfection, EGFRvIII mutant (aka Delta EGFR, d2-7 EGFR; del. exon 2-7; in-frame loss 801 bp/267 aa in EC domain)] ( 1 ) , LN428_LNZ308 (glial) [EGFR (human), transfection, EGFRvIII-ki mutant (deletion of exons 2-7 plus kinase inactive mutation)] ( 1 )

References
1	Chumbalkar V, et al. (2011) Analysis of Phosphotyrosine Signaling in Glioblastoma Identifies STAT5 as a Novel Downstream Target of ΔEGFR. J Proteome Res 10, 1343-52 21214269 Curated Info