Ser697
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Home > Phosphorylation Site Page: > Ser697  -  APP (mouse)

Site Information
FFAEDVGsNKGAIIG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 54165901

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 2 )
Relevant cell line - cell type - tissue:
brain ( 1 , 2 ) , neuron ( 2 ) , SKNSH (neural crest) ( 2 )

Downstream Regulation
Effects of modification on APP:
protein conformation ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 1 )

References 

1

Kumar S, et al. (2020) Novel Phosphorylation-State Specific Antibodies Reveal Differential Deposition of Ser26 Phosphorylated Aβ Species in a Mouse Model of Alzheimer's Disease. Front Mol Neurosci 13, 619639
33519377   Curated Info

2

Kumar S, et al. (2016) Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity. Acta Neuropathol 131, 525-37
26898910   Curated Info

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