Tyr166
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Home > Phosphorylation Site Page: > Tyr166  -  PLK1 (mouse)

Site Information
QIVLGCQyLHRNQVI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 54066600

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 1 )

Downstream Regulation
Effects of modification on PLK1:
enzymatic activity, induced ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )

References 

1

Liu X, et al. (2016) Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies. Proc Natl Acad Sci U S A 113, 984-9
26755576   Curated Info