Ser799

Site Information
MDLNsDDstDDEsHP SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 460034

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 )
Disease tissue studied:	leukemia ( 2 ) , acute myelogenous leukemia ( 2 )
Relevant cell line - cell type - tissue:	32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ( 5 ) , 32Dcl3 (myeloid) ( 5 ) , blood ( 2 ) , Hepa 1-6 (epithelial) ( 7 ) , lung ( 4 ) , MEF (fibroblast) [Raptor (mouse), knockdown] ( 1 ) , MEF (fibroblast) [RICTOR (mouse), knockdown] ( 1 ) , MEF (fibroblast) [TSC2 (mouse), homozygous knockout] ( 3 ) , MEF (fibroblast) ( 1 , 3 ) , RAW 267.4 (macrophage) ( 6 ) , spleen ( 4 ) , testis ( 4 )

Upstream Regulation
Regulatory protein:	RICTOR (mouse) ( 1 )
Treatments:	IFN-gamma ( 6 )

References
1	Robitaille AM, et al. (2013) Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 339, 1320-3 23429704 Curated Info
2	Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27 22802335 Curated Info
3	Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6 21659605 Curated Info
4	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
5	Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39 19854140 Curated Info
6	Trost M, et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30, 143-54 19144319 Curated Info
7	Pan C, Gnad F, Olsen JV, Mann M (2008) Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors. Proteomics 8, 4534-46 18846507 Curated Info