Tyr319
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Home > Phosphorylation Site Page: > Tyr319  -  AT1 (rat)

Site Information
YFLQLLKyIPPKAKS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448745

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , phosphoamino acid analysis ( 1 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 2 ) , fibroblast-heart ( 2 ) , myocyte-heart ( 1 )

Upstream Regulation
Treatments:
angiotensin ( 2 ) , angiotensin_2 ( 1 )

Downstream Regulation
Effects of modification on AT1:
activity, induced ( 2 ) , molecular association, regulation ( 2 )
Induce interaction with:
EGFR (human) ( 2 )

References 

1

Smith NJ, et al. (2011) Determination of the exact molecular requirements for type 1 Angiotensin receptor epidermal growth factor receptor transactivation and cardiomyocyte hypertrophy. Hypertension 57, 973-80
21383310   Curated Info

2

Seta K, Sadoshima J (2003) Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor. J Biol Chem 278, 9019-26
12522132   Curated Info