Ser49
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Home > Phosphorylation Site Page: > Ser49  -  STEP (rat)

Site Information
GLQERRGsNVSLTLD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448294

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , immunoprecipitation ( 3 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , phosphoamino acid analysis ( 3 ) , phosphopeptide mapping ( 3 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 1 ) , 'brain, striatum' ( 3 ) , 'neuron, cortical'-brain ( 2 )

Upstream Regulation
Putative in vivo kinases:
PKACA (rat) ( 3 )
Kinases, in vitro:
PKACA (rat) ( 3 )
Treatments:
beta-amyloid ( 1 ) , dopamine ( 3 ) , glutamic acid ( 2 ) , H-89 ( 3 ) , quinpirole ( 3 ) , SCH_23390 ( 3 ) , SKF81297 ( 3 ) , staurosporine ( 2 )

Downstream Regulation
Effects of modification on STEP:
enzymatic activity, inhibited ( 1 ) , ubiquitination ( 1 )

References 

1

Kurup P, et al. (2010) Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. J Neurosci 30, 5948-57
20427654   Curated Info

2

Paul S, Nairn AC, Wang P, Lombroso PJ (2003) NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat Neurosci 6, 34-42
12483215   Curated Info

3

Paul S, et al. (2000) The Dopamine/D1 receptor mediates the phosphorylation and inactivation of the protein tyrosine phosphatase STEP via a PKA-dependent pathway. J Neurosci 20, 5630-8
10908600   Curated Info