Ser128
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Home > Phosphorylation Site Page: > Ser128  -  CYP2B6 (rat)

Site Information
WKALRRFsLATMRDF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448738

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mutation of modification site ( 2 ) , phosphopeptide mapping ( 4 )
Relevant cell line - cell type - tissue:
hepatocyte-liver ( 1 , 4 ) , V79 (fibroblast) ( 2 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 4 )
Treatments:
cAMP_analog ( 2 )

Downstream Regulation
Effects of modification on CYP2B6:
enzymatic activity, inhibited ( 1 , 2 , 4 ) , intracellular localization ( 3 ) , protein conformation ( 4 )

References 

1

Oesch-Bartlomowicz B, Oesch F (2003) Cytochrome-P450 phosphorylation as a functional switch. Arch Biochem Biophys 409, 228-34
12464263   Curated Info

2

Oesch-Bartlomowicz B, et al. (2001) cAMP-dependent phosphorylation of CYP2B1 as a functional switch for cyclophosphamide activation and its hormonal control in vitro and in vivo. Int J Cancer 94, 733-42
11745470   Curated Info

3

Anandatheerthavarada HK, et al. (1999) Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP-dependent phosphorylation at ser128. EMBO J 18, 5494-504
10523294   Curated Info

4

Pyerin W, Taniguchi H (1989) Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450. EMBO J 8, 3003-10
2583091   Curated Info

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