Ser334
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Home > Phosphorylation Site Page: > Ser334  -  DUSP1 (human)

Site Information
AVLDRGTsTTTVFNF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 53736000

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , adipose tissue ( 1 )

Upstream Regulation
Putative in vivo kinases:
AMPKA2 (human) ( 1 )
Kinases, in vitro:
AMPKA2 (human) ( 1 )
Treatments:
metformin ( 1 ) , nicotine ( 1 )

Downstream Regulation
Effects of modification on DUSP1:
phosphorylation ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 )

References 

1

Wu Y, et al. (2015) Activation of AMPK╬▒2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. Nat Med 21, 373-82
25799226   Curated Info