Ser423

Site Information
ESRVKAtsPKsPsAA SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 457628

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 )
Relevant cell line - cell type - tissue:	BaF3 ('B lymphocyte, precursor') [JAK3 (human), transfection] ( 1 ) , lung ( 5 ) , macrophage-peritoneum [MPRIP (mouse), homozygous knockout] ( 3 ) , MEF (fibroblast) [TSC2 (mouse), homozygous knockout] ( 4 ) , RAW 264.7 (macrophage) ( 2 ) , spleen ( 5 ) , testis ( 5 )

Upstream Regulation
Regulatory protein:	RIPK3 (mouse) ( 3 )

References
1	Degryse S, et al. (2017) Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia. Leukemia 32 28852199 Curated Info
2	Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44 25367039 Curated Info
3	Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51 22942356 Curated Info
4	Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6 21659605 Curated Info
5	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info