Ser311
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Home > Phosphorylation Site Page: > Ser311  -  axin 2 (human)

Site Information
SDALTDDsMSMTDSS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 53439300

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
prostate cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PLK1 (human) ( 1 )
Kinases, in vitro:
PLK1 (human) ( 1 )
Treatments:
BI2536 ( 1 ) , nocodazole ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on axin 2:
phosphorylation ( 1 ) , protein degradation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 ) , cell cycle regulation ( 1 ) , cell growth, inhibited ( 1 ) , signaling pathway regulation ( 1 ) , transcription, inhibited ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
CRPC ( 1 )

References 

1

Li J, et al. (2015) Cotargeting Polo-Like Kinase 1 and the Wnt/β-Catenin Signaling Pathway in Castration-Resistant Prostate Cancer. Mol Cell Biol 35, 4185-98
26438599   Curated Info