Arg321
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Home > Di-methylation Site Page: > Arg321  -  SREBP-1 (human)

Site Information
APASAQSrGEkRTAH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 53350800

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )

Downstream Regulation
Effects of modification on SREBP-1:
molecular association, regulation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 ) , transcription, induced ( 1 )
Inhibit interaction with:
FBXW7 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
hepatocellular carcinoma ( 1 )

References 

1

Liu L, et al. (2016) Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth. Cancer Res 76, 1260-72
26759235   Curated Info

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