Tyr155
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Home > Phosphorylation Site Page: > Tyr155  -  CCR7 (human)

Site Information
LCIsIDRyVAIVQAV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 53340200

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 1 ) , immunoprecipitation ( 2 ) , microscopy-colocalization with upstream kinase ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 2 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 1 , 2 )
Treatments:
PP2 ( 1 )

Downstream Regulation
Effects of modification on CCR7:
molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:
cell motility, induced ( 2 ) , signaling pathway regulation ( 1 )
Induce interaction with:
RAC1 (human) ( 1 ) , SHP-2 (human) ( 2 ) , VAV1 (human) ( 1 )

References 

1

Laufer JM, et al. (2019) Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation. Cell Rep 29, 995-1009.e6
31644919   Curated Info

2

Hauser MA, et al. (2016) Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration. Immunity 44, 59-72
26789922   Curated Info

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