Thr80
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Home > Phosphorylation Site Page: > Thr80  -  Calmodulin (human)

Site Information
MARkMkDtDsEEEIr   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448704

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 5 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CK2A1 (human) ( 2 , 4 , 5 ) , CK2A1 (rat) ( 6 )

Downstream Regulation
Effects of modification on biological processes:
signaling pathway regulation ( 4 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Pan J, Zhang S, Borchers CH (2016) Protein species-specific characterization of conformational change induced by multisite phosphorylation. J Proteomics 134, 138-43
26675311   Curated Info

3

Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448   Curated Info

4

Zhang M, et al. (2014) Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex. Nat Chem Biol 10, 753-9
25108821   Curated Info

5

Allen D, Fakler B, Maylie J, Adelman JP (2007) Organization and regulation of small conductance Ca2+-activated K+ channel multiprotein complexes. J Neurosci 27, 2369-76
17329434   Curated Info

6

Arrigoni G, et al. (2004) Phosphorylation of calmodulin fragments by protein kinase CK2. Mechanistic aspects and structural consequences. Biochemistry 43, 12788-98
15461451   Curated Info