Tyr249
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Home > Phosphorylation Site Page: > Tyr249  -  GTF2I (human)

Site Information
ESEDPDyyQYNIQAG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 459606

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 3 , 4 ) , western blotting ( 3 , 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 1 )
Treatments:
genistein ( 3 ) , thapsigargin ( 3 )

Downstream Regulation
Effects of modification on GTF2I:
activity, induced ( 3 , 4 ) , intracellular localization ( 3 )
Effects of modification on biological processes:
transcription, altered ( 1 , 3 , 4 ) , transcription, induced ( 2 )

References 

1

Bu Y, Gao L, Gelman IH (2011) Role for transcription factor TFII-I in the suppression of SSeCKS/Gravin/Akap12 transcription by Src. Int J Cancer 128, 1836-42
20568114   Curated Info

2

Rajaiya J, et al. (2006) Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. Mol Cell Biol 26, 4758-68
16738337   Curated Info

3

Hong M, et al. (2005) Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: role of TFII-I and its tyrosine phosphorylation. J Biol Chem 280, 16821-8
15664986   Curated Info

4

Novina CD, Cheriyath V, Roy AL (1998) Regulation of TFII-I activity by phosphorylation. J Biol Chem 273, 33443-8
9837922   Curated Info