Ser362
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Home > Phosphorylation Site Page: > Ser362  -  Fos (rat)

Site Information
AAAHRKGsSSNEPSS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448481

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 , 4 ) , electrophoretic mobility shift ( 4 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 1 , 2 ) , phosphopeptide mapping ( 4 ) , western blotting ( 1 , 2 )
Disease tissue studied:
adrenal cancer ( 1 ) , pheochromocytoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
p90RSK (rat) ( 3 )
Treatments:
EGF ( 3 ) , MG132 ( 2 ) , NGF ( 1 ) , serum ( 3 , 4 ) , tamoxifen ( 3 ) , U0126 ( 3 )

Downstream Regulation
Effects of modification on Fos:
phosphorylation ( 3 ) , protein conformation ( 1 , 3 ) , protein stabilization ( 2 , 3 , 4 )
Effects of modification on biological processes:
cell cycle regulation ( 4 ) , transcription, altered ( 4 )

References 

1

Pellegrino MJ, Stork PJ (2006) Sustained activation of extracellular signal-regulated kinase by nerve growth factor regulates c-fos protein stabilization and transactivation in PC12 cells. J Neurochem 99, 1480-93
17223854   Curated Info

2

Ferrara P, et al. (2003) The structural determinants responsible for c-Fos protein proteasomal degradation differ according to the conditions of expression. Oncogene 22, 1461-74
12629509   Curated Info

3

Murphy LO, et al. (2002) Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol 4, 556-64
12134156   Curated Info

4

Chen RH, Juo PC, Curran T, Blenis J (1996) Phosphorylation of c-Fos at the C-terminus enhances its transforming activity. Oncogene 12, 1493-502
8622865   Curated Info