Ser19
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Home > Phosphorylation Site Page: > Ser19  -  TPH2 (human)

Site Information
YWARRGFsLDSAVPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 470085

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:
adrenal cancer ( 2 ) , pheochromocytoma ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 , 3 ) , brain ( 3 ) , Jurkat (T lymphocyte) ( 1 ) , PC-12 (chromaffin) ( 2 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 2 , 3 )
Kinases, in vitro:
CAMK2A (rat) ( 3 ) , PKACA (cow) ( 3 ) , PKACA (human) ( 2 , 4 )
Treatments:
colforsin ( 2 , 3 ) , okadaic_acid ( 3 )

Downstream Regulation
Effects of modification on TPH2:
enzymatic activity, induced ( 3 ) , molecular association, regulation ( 3 , 4 ) , protein stabilization ( 2 )
Induce interaction with:
14-3-3 beta (human) ( 4 ) , 14-3-3 epsilon (human) ( 3 ) , 14-3-3 gamma (human) ( 3 )

References 

1

Zhou J (2011) CST Curation Set: 12495; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

Murphy KL, et al. (2008) A regulatory domain in the N terminus of tryptophan hydroxylase 2 controls enzyme expression. J Biol Chem 283, 13216-24
18339632   Curated Info

3

Winge I, et al. (2008) Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. Biochem J 410, 195-204
17973628   Curated Info

4

McKinney J, Knappskog PM, Haavik J (2005) Different properties of the central and peripheral forms of human tryptophan hydroxylase. J Neurochem 92, 311-20
15663479   Curated Info

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