Tyr287
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Home > Phosphorylation Site Page: > Tyr287  -  WWOX (human)

Site Information
LSPTKNDyWAMLAYN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457684

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
liver cancer ( 1 ) , hepatocellular carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
FAM189B (human) ( 1 )
Putative in vivo kinases:
Ack (human) ( 2 )

Downstream Regulation
Effects of modification on WWOX:
protein degradation ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )

References 

1

Zhang H, et al. (2014) Upregulation of the putative oncogene COTE1 contributes to human hepatocarcinogenesis through modulation of WWOX signaling. Int J Oncol 45, 719-31
24899407   Curated Info

2

Mahajan NP, Whang YE, Mohler JL, Earp HS (2005) Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox. Cancer Res 65, 10514-23
16288044   Curated Info