Ser789
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus®
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser789  -  IRS1 (rat)

Site Information
QHLRLSSsSGRLRYT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447557

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 , 3 , 4 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 3 ) , granulosa ( 1 ) , hepatocyte-liver ( 4 )

Upstream Regulation
Putative in vivo kinases:
QIK (mouse) ( 3 )
Kinases, in vitro:
QIK (human) ( 2 ) , QIK (mouse) ( 3 )
Treatments:
urofollitropin ( 1 )

References 

1

Law NC, White MF, Hunzicker-Dunn ME (2016) G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway. J Biol Chem 291, 27160-27169
27856640   Curated Info

2

Katoh Y, et al. (2004) Salt-inducible kinase (SIK) isoforms: their involvement in steroidogenesis and adipogenesis. Mol Cell Endocrinol 217, 109-12
15134808   Curated Info

3

Horike N, et al. (2003) Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. J Biol Chem 278, 18440-7
12624099   Curated Info

4

Qiao LY, et al. (2002) In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents. J Biol Chem 277, 26530-9
12006586   Curated Info