Lys147
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Home > Sumoylation Site Page: > Lys147  -  WASP (human)

Site Information
LVQEkIQkRNQRQSG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 52504000

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 1 ) , T cell leukemia ( 1 )
Relevant cell line - cell type - tissue:
B lymphocyte ( 1 ) , dendritic cell ( 1 ) , HeLa (cervical) ( 1 ) , Jurkat (T lymphocyte) ( 1 ) , natural killer cell ( 1 ) , T lymphocyte ( 1 )

Upstream Regulation
Treatments:
N-ethylmaleimede ( 1 )

Downstream Regulation
Effects of modification on WASP:
acetylation ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 ) , transcription, altered ( 1 )
Inhibit interaction with:
COMMD1 (human) ( 1 ) , HDAC6 (human) ( 1 )

References 

1

Sarkar K, Sadhukhan S, Han SS, Vyas YM (2015) SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells. Blood 126, 1670-82
26261240   Curated Info