Ser662
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Home > Phosphorylation Site Page: > Ser662  -  PER2 (mouse)

Site Information
GKAEsVVsLTSQCSY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 470017

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
familial advanced sleep phase syndrome ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CK1D (mouse) ( 1 )

Downstream Regulation
Effects of modification on PER2:
phosphorylation ( 1 )

References 

1

Narasimamurthy R, et al. (2018) CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch. Proc Natl Acad Sci U S A 115, 5986-5991
29784789   Curated Info

2

Vanselow K, et al. (2006) Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes Dev 20, 2660-72
16983144   Curated Info