Ser199
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Home > Phosphorylation Site Page: > Ser199  -  TIF1A (human)

Site Information
IIARYVPstPWFLMP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 470003

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , phosphopeptide mapping ( 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
acadesine ( 1 ) , rapamycin ( 2 )

Downstream Regulation
Effects of modification on TIF1A:
activity, inhibited ( 2 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
transcription, altered ( 2 )
Inhibit interaction with:
TAF4 (human) ( 2 ) , eIF3S6IP (human) ( 2 )

References 

1

Hoppe S, et al. (2009) AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply. Proc Natl Acad Sci U S A 106, 17781-6
19815529   Curated Info

2

Mayer C, Zhao J, Yuan X, Grummt I (2004) mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev 18, 423-34
15004009   Curated Info