Thr363
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Home > Phosphorylation Site Page: > Thr363  -  KOR-1 (mouse)

Site Information
stNRVRNtVQDPAsM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 52467202

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 )
Disease tissue studied:
neuroblastoma ( 2 , 3 )
Relevant cell line - cell type - tissue:
brain ( 1 ) , Neuro-2a (neuron) ( 2 , 3 )

Upstream Regulation
Putative in vivo kinases:
GRK5 (mouse) ( 2 ) , GRK6 (mouse) ( 2 )
Treatments:
42B ( 1 ) , chelerythrine ( 2 ) , etorphine ( 3 ) , GF109203X ( 2 ) , Go_6976 ( 2 ) , MOM-SalB ( 1 ) , nalfurafine ( 1 ) , norBNI ( 3 ) , phorbol_ester ( 2 ) , PTX ( 2 ) , U50488 ( 1 , 2 , 3 )

Downstream Regulation
Effects of modification on KOR-1:
intracellular localization ( 3 ) , phosphorylation ( 3 ) , receptor internalization, induced ( 1 )

References 

1

Chen C, et al. (2022) Agonist-Promoted Phosphorylation and Internalization of the Kappa Opioid Receptor in Mouse Brains: Lack of Connection With Conditioned Place Aversion. Front Pharmacol 13, 835809
35652052   Curated Info

2

Chiu YT, et al. (2017) Agonist-Dependent and -Independent κ Opioid Receptor Phosphorylation: Distinct Phosphorylation Patterns and Different Cellular Outcomes. Mol Pharmacol 92, 588-600
28893975   Curated Info

3

Chen C, et al. (2016) Determination of sites of U50,488H-promoted phosphorylation of the mouse κ opioid receptor (KOPR): disconnect between KOPR phosphorylation and internalization. Biochem J 473, 497-508
26635353   Curated Info

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