Ser356
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Home > Phosphorylation Site Page: > Ser356  -  KOR-1 (mouse)

Site Information
KMRMERQstNRVRNt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 52467200

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 , 2 )
Relevant cell line - cell type - tissue:
Neuro-2a (neuron) ( 1 , 2 )

Upstream Regulation
Putative in vivo kinases:
GRK2 (mouse) ( 1 ) , GRK3 (mouse) ( 1 ) , GRK5 (mouse) ( 1 ) , GRK6 (mouse) ( 1 )
Treatments:
etorphine ( 2 ) , GF109203X ( 1 ) , Go_6976 ( 1 ) , norBNI ( 2 ) , phorbol_ester ( 1 ) , PTX ( 1 ) , U50488 ( 1 , 2 )

Downstream Regulation
Effects of modification on KOR-1:
intracellular localization ( 2 ) , receptor internalization, induced ( 1 )

References 

1

Chiu YT, et al. (2017) Agonist-Dependent and -Independent κ Opioid Receptor Phosphorylation: Distinct Phosphorylation Patterns and Different Cellular Outcomes. Mol Pharmacol 92, 588-600
28893975   Curated Info

2

Chen C, et al. (2016) Determination of sites of U50,488H-promoted phosphorylation of the mouse κ opioid receptor (KOPR): disconnect between KOPR phosphorylation and internalization. Biochem J 473, 497-508
26635353   Curated Info

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