Ser246
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Home > Phosphorylation Site Page: > Ser246  -  CTNNB1 (human)

Site Information
ALVKMLGsPVDSVLF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 469995

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CDK5 (human) ( 3 )

Downstream Regulation
Effects of modification on CTNNB1:
intracellular localization ( 1 ) , molecular association, regulation ( 1 , 3 ) , protein conformation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )
Induce interaction with:
PIN1 (human) ( 1 , 3 )

References 

1

Shin HR, et al. (2016) Pin1-mediated Modification Prolongs the Nuclear Retention of β-Catenin in Wnt3a-induced Osteoblast Differentiation. J Biol Chem 291, 5555-65
26740630   Curated Info

2

Yin N, et al. (2016) p38γ MAPK is required for inflammation-associated colon tumorigenesis. Oncogene 35, 1039-48
25961922   Curated Info

3

Muñoz JP, Huichalaf CH, Orellana D, Maccioni RB (2007) cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells. J Cell Biochem 100, 738-49
17009320   Curated Info