Ser117
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Home > Phosphorylation Site Page: > Ser117  -  SREBP-1 (human)

Site Information
YPSMPAFsPGPGIkE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 469986

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 4 ) , electrophoretic mobility shift ( 5 ) , mass spectrometry ( 1 , 2 , 6 ) , mass spectrometry (in vitro) ( 4 , 8 ) , mutation of modification site ( 4 , 5 , 8 ) , western blotting ( 4 , 5 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , liver cancer ( 4 , 5 , 8 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , E.coli (bacterial) ( 4 ) , HeLa (cervical) ( 2 , 6 ) , hepatic ( 4 ) , HepG2 (hepatic) ( 4 , 5 , 8 )

Upstream Regulation
Regulatory protein:
MKK4 (human) ( 4 )
Putative in vivo kinases:
ERK1 (human) ( 5 ) , ERK2 (human) ( 5 ) , JNK1 (human) ( 4 )
Kinases, in vitro:
ERK1 (human) ( 8 ) , ERK2 (human) ( 8 ) , JNK1 (human) ( 4 ) , JNK2 (human) ( 4 )
Treatments:
GH ( 5 ) , PD98059 ( 5 ) , wortmannin ( 5 )

Downstream Regulation
Effects of modification on SREBP-1:
sumoylation ( 7 )
Effects of modification on biological processes:
transcription, altered ( 5 ) , transcription, induced ( 4 , 7 , 8 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

4

Kotzka J, et al. (2012) Preventing Phosphorylation of Sterol Regulatory Element-Binding Protein 1a by MAP-Kinases Protects Mice from Fatty Liver and Visceral Obesity. PLoS One 7, e32609
22384276   Curated Info

5

Kotzka J, et al. (2010) Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes. Atherosclerosis 213, 156-65
20863500   Curated Info

6

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

7

Arito M, et al. (2008) Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis. J Biol Chem 283, 15224-31
18403372   Curated Info

8

Roth G, et al. (2000) MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro. J Biol Chem 275, 33302-7
10915800   Curated Info