Thr508
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Home > Phosphorylation Site Page: > Thr508  -  LIMK1 (rat)

Site Information
PDRKKRYtVVGNPYW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447808

In vivo Characterization
Methods used to characterize site in vivo:
microscopy-colocalization with upstream kinase ( 3 ) , mutation of modification site ( 1 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
'neuron, dorsal root ganglion'-brain ( 1 ) , REF (fibroblast) ( 2 ) , RIE (epithelial) ( 3 )

Upstream Regulation
Regulatory protein:
ILK (human) ( 3 ) , ROCK1 (rat) ( 2 )
Treatments:
cell_adhesion ( 3 ) , Y27632 ( 2 )

References 

1

Li Y, et al. (2014) LIMK-Dependent Actin Polymerization in Primary Sensory Neurons Promotes the Development of Inflammatory Heat Hyperalgesia in Rats. Sci Signal 7, ra61
24962708   Curated Info

2

Park JH, Arakawa-Takeuchi S, Jinno S, Okayama H (2011) Rho-associated Kinase Connects a Cell Cycle-controlling Anchorage Signal to the Mammalian Target of Rapamycin Pathway. J Biol Chem 286, 23132-41
21561859   Curated Info

3

Kim YB, et al. (2008) Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complex. J Biol Chem 283, 10089-96
18252715   Curated Info