Thr505
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Home > Phosphorylation Site Page: > Thr505  -  LIMK2 (rat)

Site Information
SDRKKRYtVVGNPYW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448683

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 3 ) , phosphoamino acid analysis ( 3 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'neuron, dorsal root ganglion'-brain ( 1 ) , COS (fibroblast) ( 3 ) , HeLa (cervical) ( 3 )

Upstream Regulation
Putative in vivo kinases:
ROCK1 (rat) ( 3 )
Kinases, in vitro:
MRCKA (rat) ( 2 )

Downstream Regulation
Effects of modification on LIMK2:
activity, induced ( 3 )

References 

1

Li Y, et al. (2014) LIMK-Dependent Actin Polymerization in Primary Sensory Neurons Promotes the Development of Inflammatory Heat Hyperalgesia in Rats. Sci Signal 7, ra61
24962708   Curated Info

2

Sumi T, Matsumoto K, Shibuya A, Nakamura T (2001) Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. J Biol Chem 276, 23092-6
11340065   Curated Info

3

Sumi T, Matsumoto K, Nakamura T (2001) Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. J Biol Chem 276, 670-6
11018042   Curated Info