Tyr147

Site Information
DyKKLAPyNIRRsst SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 5204724

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 )
Disease tissue studied:	esophageal cancer, surrounding tissue ( 2 ) , gastric cancer ( 1 ) , gastric carcinoma ( 1 )
Relevant cell line - cell type - tissue:	esophagus ( 2 ) , MKN-45 (gastric) ( 1 , 3 )

Upstream Regulation
Treatments:	Su11274 ( 1 )

References
1	Moritz A, et al. (2010) Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases. Sci Signal 3, ra64 20736484 Curated Info
2	Gu T (2009) CST Curation Set: 7077; Year: 2009; Biosample/Treatment: tissue, esophagus/untreated; Disease: esophageal cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
3	Rush J (2008) CST Curation Set: 4495; Year: 2008; Biosample/Treatment: cell line, MKN-45/untreated &'\|\|' normal; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS/T) Immunoaffinity Beads Cat#: 1978 Curated Info